FBXW5 Gene
protein-coding GIFtS: 51
GCID: GC09M139834
|
|
F-box and WD repeat domain containing 5(Previous name: F-box and WD-40 domain protein 5 )
| |
Aliases
for FBXW5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box And WD Repeat Domain Containing 51 2 | | F-Box And WD-40 Domain Protein 51 | | Fbw51 2 | | F-Box/WD Repeat-Containing Protein 52 | | F-Box And WD-40 Domain-Containing Protein 52 3 | | WD Repeat-Containing F-Box Protein FBW52 | | DKFZP434B2051 | | FBW53 | | MGC209621 | | |
Export aliases for FBXW5 gene to outside databasesPrevious GC identifers: GC09M131098 GC09M131524 GC09M133275 GC09M135192 GC09M137110 GC09M138954 GC09M109294 |
Summaries
for FBXW5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXW5:
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 aminoacid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complexcalled SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins aredivided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containingeither different protein-protein interaction modules or no recognizable motifs. The protein encoded by this genecontains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively splicedtranscript variants encoding distinct isoforms have been identified for this gene, however, they were found to benonsense-mediated mRNA decay (NMD) candidates, hence not represented. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6Function: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligasecomplex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading toprevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation ofactin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changesrequired to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligasecomplex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulatorof MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway
Gene Wiki entry for FBXW5
|
Genomic Views
for FBXW5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_024000.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXW5 gene promoter:
USF1 p53 AML1a AP-1 AP-2gamma HEN1 PPAR-gamma1 USF-1 STAT3 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXW5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3FBXW5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M139834: view genomic region
(about GC identifiers)
Start:
|
139,834,887 bp from pter |
End:
|
139,839,173 bp from pter |
Size:
|
4,287 bases |
Orientation:
|
minus strand |
|
Proteins
for FBXW5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6 (See
protein sequence)Recommended Name: F-box/WD repeat-containing protein 5 Size: 566 amino acids; 63922 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXW5) composed of CUL1, SKP1, RBX1and FBXW5. Component of the DCX(FBXW5) E3 ubiquitin ligase complex, at least composed of (CUL4A or CUL4B), DDB1, FBXW5and RBX1. Interacts with CDC20, EPS8, TSC1, TSC2 and SASS6
Subcellular location: Cytoplasm
Developmental stage: Degraded by the APC/C complex during G1 phase and reaccumulates at the G1/S phase transition
Sequence caution: Sequence=AAG17240.1; Type=Frameshift; Positions=Several; Sequence=AAG23772.1; Type=Frameshift;Positions=Several; Sequence=AAH00850.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAI12741.1; Type=Erroneous gene model prediction; Sequence=CAI12744.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RDZ6 Q59ET5 Q5SPZ8 Q5SPZ9 Q5SQ00 Q5SQ02 Q5SQ03 Q5SQ04 Q8WY79 Q96GJ6 Q9BSU8Q9H6A8 Q9HBQ6 Q9NSZ3Alternative splicing: 2 isoforms: Q969U6-1 Q969U6-2 Explore the universe of human proteins at neXtProt for FBXW5: NX_Q969U6
Post-translational modifications:
Phosphorylated at Ser-151 by PLK4 during the G1/S transition, leading to inhibit its ability to ubiquitinate SASS61
Ubiquitinated and degraded by the APC/C complex during mitosis and G1 phase1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969U6
FBXW5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061871.1
ENSEMBL proteins: ENSP00000313034 ENSP00000409102 ENSP00000404829 ENSP00000394011 Reactome Protein details: Q969U6
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FBXW5 for ontologies About GeneDecksing
FBXW5 Antibody Products:
Assay Products for FBXW5: |
Protein
Domains /
Families
for FBXW5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXW5 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q969U6ProtoNet protein and cluster: Q969U6 UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6Domain: The F-box domain mediates interaction with components of SCF (SKP1-CUL1-F-box protein) complexes, while WDrepeats mediate interaction with components of DCX (DDB1-CUL4-X-box) complexes (Probable)Domain: The D-box (destruction box) mediate the interaction with APC proteins, and acts as a recognition signal fordegradation via the ubiquitin-proteasome pathway (By similarity)Similarity: Belongs to the FBXW5 familySimilarity: Contains 1 F-box domainSimilarity: Contains 3 WD repeats |
Function
for FBXW5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6Function: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligasecomplex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading toprevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation ofactin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changesrequired to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligasecomplex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulatorof MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBXW5 (NM_018998) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXW5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW5 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
FBXW5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FBXW5:
|
Pathways & Interactions
for FBXW5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chaperonin-mediated protein folding | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for FBXW5
UniProtKB/Swiss-Prot: FBXW5_HUMAN, Q969U6Pathway: Protein modification; protein ubiquitination
FBXW5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXW5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/61 Interacting proteins for FBXW5 (Q969U61, 2, 3 ENSP000003130344) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| UBE2R2 | Q712K32, 3, ENSP000002632284 | MINT-8276263 I2D:
score=2 STRING: ENSP00000263228 | | CUL1 | Q136162, 3, ENSP000003268044 | MINT-49912 I2D:
score=1 STRING: ENSP00000326804 | | SKP1 | P632081, 3, ENSP000002314874 | EBI-741068,EBI-307486 I2D:
score=3 STRING: ENSP00000231487 | | KRTAP4-12 | Q9BQ662, 3, ENSP000003775824 | MINT-66140 I2D:
score=5 STRING: ENSP00000377582 | | MDFI | Q997502, 3, ENSP000002303214 | MINT-67271 I2D:
score=5 STRING: ENSP00000230321 |
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- | | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
IDA | -- | | GO:0043161 | proteasomal ubiquitin-dependent protein catabolic process |
IDA | 18381890 | | GO:0051298 | centrosome duplication |
IMP | -- |
FBXW5 for ontologies About GeneDecksing
|
Drugs & Compounds
for FBXW5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXW5
Search CenterWatch for drugs/clinical trials and news about FBXW5
|
Transcripts
for FBXW5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXW5 gene (3 alternative transcripts): NM_018998.3 NM_178225.1 NM_178226.1 Unigene Cluster for FBXW5: F-box and WD repeat domain containing 5 Hs.522507 [show with all ESTs]Unigene Representative Sequence: NM_0189989 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000487794(uc010nbx.3) ENST00000325285 ENST00000483559(uc004cjx.3 uc004cjy.3)
ENST00000459905(uc004cjz.3) ENST00000433269 ENST00000480818 ENST00000491246
ENST00000428398 ENST00000443788
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FBXW5 (NM_018998) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXW5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW5 |
Additional cDNA sequence: AB209726.1 AF217998.1 AF258569.1 AK026081.1 AK315738.1 BC000850.1 BC004541.2 BC009429.1 BC014130.1 BC014297.2 17 DOTS entries: DT.455308 DT.100650209 DT.100841693 DT.100650211 DT.92447605 DT.100874650 DT.97854711 DT.92447602 DT.100650214 DT.121200994 DT.95373095 DT.95373102 DT.100696621 DT.121201000 DT.92447607 DT.92447608 DT.97772989 24/442 AceView cDNA sequences (see all 442): BU683604 BI820489 BQ772175 BQ950302 BC035355 BM680447 NM_178226 BM852485 BM726086 BG818903 BC000850 BI160516 AK026081 BM678295 BM848274 BC014130 BM757147 AI970077 BM711965 BM719811 BC004541 BI909648 NM_018998 BQ669544
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXW5 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBXW5
|
Expression
for FBXW5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXW5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCACGCACC
About this image
See FBXW5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXW5
SOURCE GeneReport for Unigene cluster: Hs.522507
SABiosciences Expression via Pathway-Focused PCR Array including FBXW5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXW5
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW5 |
Orthologs
for FBXW5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBXW5 gene from 6/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fbxw51 , 5 |
F-box and WD-40 domain protein 51, 5 |
85.46(n)1
90.25(a)1 |
|
2 (17.31 cM)5
308391 NM_013908.41 NP_038936.11
255007505 |
chicken
(Gallus gallus) |
Aves |
FBXW51 |
F-box and WD repeat domain containing 5 |
75.1(n)
78.25(a) |
|
417289 NM_001030694.1 NP_001025865.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FBXW56 |
-- |
62(a) |
1 ↔ 1 |
GL343888.1(37840-42879) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.65342 |
Xenopus laevis transcribed sequence with weak similarity more |
79.16(n) |
|
BI442107.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.283842 |
Danio rerio cDNA clone MGC63874 IMAGE6789527, complete more |
76.34(n) |
|
BC057409.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Fbw51 |
CG9144-PA |
56.22(n)
45.83(a) |
|
33854 NM_135145.1 NP_608989.1 |
ENSEMBL Gene Tree for FBXW5 (if available)
TreeFam Gene Tree for FBXW5 (if available) |
Paralogs
for FBXW5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXW5 gene
- WDR262
FBXW5 for paralogs About GeneDecksing
|
Genomic Variants
for FBXW5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXW5 (139834887 - 139839173 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FBXW5
3 CNVs: 9631 30350 5415 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXW5 |
|
Disorders
/ Diseases
for FBXW5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXW5 for disorders About GeneDecksing
OMIM gene information: 609072
OMIM disorders: --
3  diseases for FBXW5: About MalaCardstuberous sclerosis hepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: FBXW5 (1 document)
Export disorders for FBXW5 gene to outside databases
|
Publications
for FBXW5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXW5 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with FBXW5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. (PubMed id 21725316)1, 2 Puklowski A....Malek N.P. (2011)
- An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway. (PubMed id 19232515)1, 2 Minoda Y....Takaesu G. (2009)
- WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. (PubMed id 18381890)1, 2 Hu J....Xiong Y. (2008)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Fbxw7a- and GSK3-mediated degradation of p100 is a pro -survival mechanism in multiple myeloma. (PubMed id 22388891)1 Busino L....Pagano M. (2012)
- Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4- Rbx1 ligase-mediated sumoylation. (PubMed id 22910413)1 Kanei-Ishii C....Ishii S. (2012)
|
External Searches for FBXW5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXW5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing FBXW5 gene
(According to HUGE)
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Specialized Databases showing FBXW5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for FBXW5 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for FBXW5 gene:
Search GeneIP for patents involving FBXW5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FBXW5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXW5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXW5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FBXW5 | | OriGene 3'-UTR Clone for FBXW5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXW5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FBXW5 | | OriGene Custom Protein Services for FBXW5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXW5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXW5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXW5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXW5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXW5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXW5 |
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| | | | Search Tocris compounds for FBXW5 |
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 | | | FBXW5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXW5 |
|  |  |  | | | | Search ThermoFisher Antibodies for FBXW5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXW5 |
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