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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ENPP7 Gene

protein-coding   GIFtS: 52
GCID: GC17P077704

ectonucleotide pyrophosphatase/phosphodiesterase 7

 Explore 9 diseases affiliated with
ENPP7 via our new
 Human Malady Compendium 
Biological research products
for ENPP7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ectonucleotide Pyrophosphatase/Phosphodiesterase 71 2     ALK-SMase2
Alkaline Sphingomyelin Phosphodiesterase2 3     Alkaline Sphingomyelinase2
Intestinal Alkaline Sphingomyelinase2 3     Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 72
NPP-72 3     Alk-SMase3
E-NPP 72 3     EC 3.1.4.123
Alk-SMase3     

External Ids:    HGNC: 237641   Entrez Gene: 3392212   Ensembl: ENSG000001821567   UniProtKB: Q6UWV63   

Export aliases for ENPP7 gene to outside databases

Previous GC identifers: GC17P078406 GC17P075319 GC17P073145


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ENPP7_HUMAN, Q6UWV6
Function: Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine.
Does not appear to have nucleotide pyrophosphatase activity

Gene Wiki entry for ENPP7


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ENPP7 gene promoter:
         STAT1   Bach2   STAT1beta   XBP-1   Arnt   STAT1alpha   FAC1   HOXA5   ARP-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidENPP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ENPP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ENPP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

ENPP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ENPP7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P077704:  view genomic region     (about GC identifiers)

Start:
77,704,681 bp from pter      End:
77,716,021 bp from pter
Size:
11,341 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ENPP7_HUMAN, Q6UWV6 (See protein sequence)
Recommended Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor  
Size: 458 amino acids; 51494 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential). Note=Localized at the surface of the
microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar
membrane, and in Golgi complex
Miscellaneous: Decreased levels of alkaline sphingomyelin phosphodiesterase may be associated with colon cancer
Secondary accessions: Q6ZTS5 Q8IUS8

Explore the universe of human proteins at neXtProt for ENPP7: NX_Q6UWV6

Post-translational modifications:

  • N-glycosylated; required for activity and transport to the plasma membrane1
  • View neXtProt modification sites for NX_Q6UWV6

  • ENPP7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_848638.2  
    ENSEMBL proteins: 
     ENSP00000332656   ENSP00000460429  
    Reactome Protein details: Q6UWV6
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IDA12671034
    GO:0005886plasma membrane TAS--
    GO:0005902microvillus IDA12671034
    GO:0016020membrane NAS12885774
    GO:0016021integral to membrane IEA--


    ENPP7 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ENPP7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002591 Phosphodiest/P_Trfase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR024873 E-NPP
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry Q6UWV6

    ProtoNet protein and cluster: Q6UWV6

    UniProtKB/Swiss-Prot: ENPP7_HUMAN, Q6UWV6
    Similarity: Belongs to the nucleotide pyrophosphatase/phosphodiesterase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ENPP7_HUMAN, Q6UWV6
    Function: Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine.
    Does not appear to have nucleotide pyrophosphatase activity
    Catalytic activity: Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine
    Enzyme regulation: Inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Not inhibited by
    ADP, AMP and EDTA

    Enzyme Number (IUBMB): EC 3.1.4.121

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    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004767sphingomyelin phosphodiesterase activity IDA12671034


    ENPP7 for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for ENPP7:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased focal adhesion (FA)  
     Decreased nuclei size in G2M  Increased HPV18 LCR reporter a  Low eccentricity cells 

    Animal Models:
         Mouse knock-outs for ENPP7: Enpp7tm1Rudd Enpp7tm1Lex
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Enpp7):
     digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  tumorigenesis 

    ENPP7 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sphingolipid metabolism
    Sphingolipid metabolism1.00
    Sphingolipid metabolism0.54
    Glycosphingolipid metabolism0.54
    2Metabolism
    Metabolism1.00
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.38
    3sphingomyelin metabolism
    sphingomyelin metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for ENPP7 
        sphingomyelin metabolism

    4        Reactome Pathways for ENPP7
        Sphingolipid metabolism
    Glycosphingolipid metabolism
    Metabolism
    Metabolism of lipids and lipoproteins


    2         Kegg Pathways  (Kegg details for ENPP7):
        Sphingolipid metabolism
    Metabolic pathways


    ENPP7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ENPP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/23 Interacting proteins for ENPP7 (Q6UWV63 ENSP000003326564) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ACER1ENSP000003014524STRING: ENSP00000301452
    ACER2ENSP000003426094STRING: ENSP00000342609
    ASAH1ENSP000003711524STRING: ENSP00000371152
    ASAH2ENSP000003788974STRING: ENSP00000378897
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006684sphingomyelin metabolic process IDA12671034
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0008156negative regulation of DNA replication IDA12671034


    ENPP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ENPP7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ENPP7

    10/152 HMDB Compounds for ENPP7 (see all 152)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--
    3-O-Sulfogalactosylceramide (d18:1/26:1(17Z))Sulfatide (d18:1/26:1(17Z)) (see all 13)928346-40-1--
    9 Novoseek chemical compound relationships for ENPP7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    npps 81.2 1 12885774 (1)
    ceramide 78.2 7 17490747 (1), 18353542 (1), 16255717 (1), 18354751 (1) (see all 5)
    sphingosine 69.2 5 16963225 (1), 18354751 (1), 19027789 (1), 16251722 (1)
    glycocholate 67.9 1 9508530 (1)
    phosphorylcholine 65.6 2 12885774 (1), 16255717 (1)
    taurocholate 63.3 1 9508530 (1)
    lysophosphatidylcholine 48 1 12885774 (1)
    phosphatidylcholine 34 1 9328299 (1)
    cholesterol 11.1 2 15708357 (1)

    Search CenterWatch for drugs/clinical trials and news about ENPP7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ENPP7 gene: 
    NM_178543.3  

    Unigene Cluster for ENPP7:

    Ectonucleotide pyrophosphatase/phosphodiesterase 7
    Hs.114084  [show with all ESTs]
    Unigene Representative Sequence: AK126250
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328313(uc002jxa.3) ENST00000576512

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    Additional cDNA sequence: 

    AK126250.1 AY230663.1 AY358622.1 BC041453.1 

    2 DOTS entries:

    DT.101980735  DT.101954128 

    12 AceView cDNA sequences:

    AY358622 NM_178543 AK128662 BI765770 AI640575 AK126250 AI469333 AY230663 
    BC041453 AA701973 AA702650 AA938521 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ENPP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAATAAAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ENPP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ENPP7

    SOURCE GeneReport for Unigene cluster: Hs.114084

    UniProtKB/Swiss-Prot: ENPP7_HUMAN, Q6UWV6
    Tissue specificity: Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low
    levels in the ileum. Expression was very low in the esophagus, stomach and colon

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ENPP7 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ENPP76
    Uncharacterized protein
    63(a)
    1 ↔ 1
    18(9621491-9626225)
    lizard
    (Anolis carolinensis)
    Reptilia ENPP76
    --
    64(a)
    1 ↔ 1
    2(101017189-101035993)
    zebrafish
    (Danio rerio)
    Actinopterygii si:busm1-64d20.26
    CT573006.16
    (see all 4)
    --
    46(a)
    46(a)
    (see all 4)
    1 ↔ many
    1 ↔ many
    (see all 4)
    12(34389509-34392765)
    12(34101461-34108950)
    worm
    (Caenorhabditis elegans)
    Secernentea C01B10.96
    Protein C01B10.9
    19(a)
    1 ↔ 1
    IV(6632211-6634987)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G297106
    AT4G296906
    (see all 4)
    alkaline-phosphatase-like protein
    (see all 4)
    28(a)
    26(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    4(14547001-14547402)
    4(14540907-14542481)
    rice
    (Oryza sativa)
    Liliopsida --
    ectonucleotide pyrophosphatase/phosphodiesterase f...
    23(a)
    1 → many
    1(5217542-5219398)


    ENSEMBL Gene Tree for ENPP7 (if available)
    TreeFam Gene Tree for ENPP7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ENPP7 gene
    ENPP32  ENPP62  ENPP12  ENPP52  ENPP42  ENPP22  
    4 SIMAP similar genes for ENPP7 using alignment to 2 protein entries:     ENPP7_HUMAN (see all proteins):
    ENPP5    ENPP4    ENPP6    ENPP3

    ENPP7 for paralogs           About GeneDecksing


    5/16 Pseudogenes.org Pseudogenes for ENPP7 (see all 16)
    PGOHUM00000242122 PGOHUM00000242342 PGOHUM00000242783 PGOHUM00000239318 PGOHUM00000248711


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/357 NCBI SNPs in ENPP7 are shown (see all 357    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406008501,2
    --77702925(+) AGCCAA/GACCTC 1 -- us2k10--------
    rs1890524731,2
    --77702980(+) GTGGTG/TGCAGG 1 -- us2k10--------
    rs1929471381,2
    --77703118(+) CGTACA/CAGTGG 1 -- us2k10--------
    rs99104291,2
    C,F,A,H,--77703172(+) GCTGTG/AGACGG 1 -- us2k112Minor allele frequency- A:0.48NA WA CSA EA 375
    rs568860071,2
    --77703203(+) TGCCAC/TGGCCA 1 -- us2k10--------
    rs1141522931,2
    --77703220(+) CGAGAC/TGGCGT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1450374611,2
    --77703381(+) TCCAGC/TGCACC 1 -- us2k10--------
    rs1177753721,2
    F,--77703557(+) ATGGAG/AAGTAT 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs116535771,2
    C,F,A,H,--77703608(+) AACCCG/CCGCCT 1 -- us2k112Minor allele frequency- C:0.50NA WA CSA EA 375
    rs1847473281,2
    --77703748(+) CTCAGC/TGAGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ENPP7 (77704681 - 77716021 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ENPP7
         2 CNVs: 73051 0213

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ENPP7 for disorders           About GeneDecksing

    9 diseases for ENPP7:    About MalaCards
    familial adenomatous polyposis    fanconi's anemia    polyposis    colon carcinoma
    colon cancer    anemia    carcinoma    colorectal cancer
    cholesterol

    10 Novoseek disease relationships for ENPP7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 61.9 10 15016655 (2), 10522612 (2), 16631405 (1), 16255717 (1) (see all 5)
    familial adenomatous polyposis 55.1 2 12774245 (1), 10496347 (1)
    colon carcinoma 43.3 1 12920578 (1)
    adenoma 42.3 4 10496347 (3), 9508530 (1)
    colorectal carcinoma 27.6 1 9028353 (1)
    inflammatory bowel diseases 18.4 1 16631405 (1)
    adenocarcinoma 14.1 2 15824156 (1), 10496347 (1)
    cancer 1.5 1 9508530 (1)
    tumors 0 8 12774245 (2), 15824156 (2)
    carcinoma 0 1 9508530 (1)


    Export disorders for ENPP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ENPP7 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with ENPP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. (PubMed id 12885774)1, 2, 3, 9 Duan R.-D.... Nilsson A. (2003)
    2. Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation- related expression of the wild-type enzyme in Caco-2 cells. (PubMed id 15016655)1, 2, 9 Wu J.... Duan R.-D. (2004)
    3. Functional studies of human intestinal alkaline sphingomyelinase by deglycosylation and mutagenesis. (PubMed id 15458386)1, 2, 9 Wu J.... Duan R.-D. (2005)
    4. Purification, localization, and expression of human intestinal alkaline sphingomyelinase. (PubMed id 12671034)1, 2, 9 Duan R.-D.... Nilsson A. (2003)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity. (PubMed id 16255717)1, 9 Wu J....Duan R.D. (2006)
    10. Cloning of alkaline sphingomyelinase from rat intestinal mucosa and adjusting of the hypothetical protein XP_221184 in GenBank. (PubMed id 15708357)1, 9 Wu J....Duan R.D. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339221 HGNC: 23764 AceView: ENPP7 Ensembl:ENSG00000182156 euGenes: HUgn339221
    ECgene: ENPP7 Kegg: 339221 H-InvDB: ENPP7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ENPP7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ENPP7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ENPP7 gene:
    Search GeneIP for patents involving ENPP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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