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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCT Gene

protein-coding   GIFtS: 59
GCID: GC13M095091

dopachrome tautomerase

(Previous name: tyrosine-related protein 2 )
(Previous symbol: TYRP2)
 Explore 19 diseases affiliated with
DCT via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DCT    

Aliases
for DCT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dopachrome Tautomerase1 2     TRP22 3
TYRP21 2 3 5     L-Dopachrome Delta-Isomerase2 3
Tyrosine-Related Protein 21 2     EC 5.3.3.123 8
Tyrosinase-Related Protein 22 3     Dopachrome Delta-Isomerase2
DT2 3     Dopachrome Tautomerase (Dopachrome Delta-Isomerase, Tyrosine-Related Protein 2)2
TRP-22 3     L-Dopachrome Tautomerase2

External Ids:    HGNC: 27091   Entrez Gene: 16382   Ensembl: ENSG000000801667   OMIM: 1912755   UniProtKB: P401263   

Export aliases for DCT gene to outside databases

Previous GC identifers: GC13M093451 GC13M089476 GC13M093926 GC13M092789 GC13M093889 GC13M075688


Summaries
for DCT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126
Function: Involved in regulating eumelanin and phaeomelanin levels

Gene Wiki entry for DCT (Dopachrome tautomerase)


Genomic Views
for DCT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCT gene promoter:
         ISGF-3   HSF1 (long)   CUTL1   LCR-F1   SRY   PPAR-gamma1   FOXO4   Chx10   HSF1short   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DCT promoter sequence
   Search SABiosciences Chromatin IP Primers for DCT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q32

DCT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCT gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M095091:  view genomic region     (about GC identifiers)

Start:
 95,091,741 bp from pter      End:
 95,131,936 bp from pter
Size:
 40,196 bases      Orientation:
 minus strand

Proteins
for DCT gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126 (See protein sequence)
Recommended Name: L-dopachrome tautomerase precursor  
Size: 519 amino acids; 59145 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Subunit: Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex (By similarity)
Subcellular location: Melanosome membrane; Single-pass type I membrane protein
Secondary accessions: Q09GT4
Alternative splicing: 2 isoforms:  P40126-1   P40126-2   

Explore the universe of human proteins at neXtProt for DCT: NX_P40126

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P40126

    • 4/8 DME Specific Peptides for DCT (P40126) (see all 8)
     HSFLNGT  SFRNALEGF  ELAPIGHNR  CTGNFAGYNCG 

    DCT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123361.1  NP_001913.2  

    ENSEMBL proteins: 
     ENSP00000431275   ENSP00000366227   ENSP00000392762  

    Human Recombinant Protein Products: 
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    Novus Biologicals DCT Lysate
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    Uscn Proteins for DCT

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005792microsome ----
    GO:0005829cytosol ISS--
    GO:0016021integral to membrane IEA--
    GO:0033162melanosome membrane IEA--


    DCT for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DCT gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DCT for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002227 Tyrosinase
     IPR008922 Unchr_di-copper_centre

    Graphical View of Domain Structure for InterPro Entry P40126

    ProtoNet protein and cluster: P40126

    1 Blocks protein family: IPB002227 Tyrosinase copper-binding domain signature

    UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126
    Similarity: Belongs to the tyrosinase family


    Function
    for DCT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126
    Function: Involved in regulating eumelanin and phaeomelanin levels
    Catalytic activity: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate

         Genatlas biochemistry entry for DCT:
    DOPAchrome tautomerase

    Enzyme Number (IUBMB): EC 5.3.3.121 2

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: DCT 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: DCT
    OriGene siRNA: DCT
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004167dopachrome isomerase activity ISS--
    GO:0005507copper ion binding TAS8206391
    GO:0016491oxidoreductase activity IEA--
    GO:0046872metal ion binding ----


    DCT for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DCT:
     Decreased TP53 protein express 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Dct):
     integument  nervous system  pigmentation  vision/eye 

    DCT for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DCT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neural Crest Differentiation
    		Neural Crest Differentiation1.00
    2Tyrosine metabolism
    		Tyrosine metabolism1.00
    3Metabolism
    		Metabolic pathways0.38
    4Basal cell carcinoma
    		Melanogenesis0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for DCT 
        Neural Crest Differentiation


    3         Kegg Pathways  (Kegg details for DCT):
        Tyrosine metabolism
    Metabolic pathways
    Melanogenesis

    UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126
    Pathway: Pigment biosynthesis; melanin biosynthesis


    DCT for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DCT

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for DCT (P401263 ENSP000003927624) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCLP182063I2D: score=1 
    TYRP1ENSP000003735704STRING: ENSP00000373570
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002052positive regulation of neuroblast proliferation IEA--
    GO:0006583melanin biosynthetic process from tyrosine ISS--
    GO:0008544epidermis development TAS8206391
    GO:0021847ventricular zone neuroblast division IEA--
    GO:0042438melanin biosynthetic process ----


    DCT for ontologies           About GeneDecksing



    Drugs & Compounds
    for DCT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DCT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCT

    3 HMDB Compounds for DCT    About this table
    CompoundSynonyms CAS #PubMed Ids
    5,6-DihydroxyindoleDHI;dopaminochrome (see all 2)3131-52-0--
    5,6-Dihydroxyindole-2-carboxylic acid5,6-Dhica (see all 10)4790-08-3--
    L-Dopachrome2-L-carboxy-2,3-dihydroindole-5,6-quinone (see all 2)89762-39-0--
    10/28 Novoseek chemical compound relationships for DCT gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dopachrome 98.3 192 1511683 (5), 9794786 (4), 11851878 (3), 1859367 (3) (see all 87)
    l-dopachrome 91.8 12 7980602 (1), 9794786 (1), 9756992 (1), 11095412 (1) (see all 7)
    dhica 91 16 12753395 (2), 1511683 (2), 7761345 (1), 7659683 (1) (see all 11)
    eumelanin 85.8 12 7761345 (1), 12753395 (1), 19449448 (1), 7567792 (1) (see all 8)
    5,6-dihydroxyindole 84.2 12 1511683 (2), 18435614 (1), 1958700 (1), 9792924 (1) (see all 5)
    dopaquinone 79 1 11041367 (1)
    levodopa 54.7 14 11180971 (1), 11549110 (1), 7659681 (1), 1511683 (1) (see all 7)
    hmba 51.1 7 11310793 (3), 10080955 (1)
    arbutin 44.9 4 9711535 (2), 10625956 (1)
    ibmx 40.9 2 7533905 (1), 9730320 (1)

    Search CenterWatch for drugs/clinical trials and news about DCT / TYRP2 

    Transcripts
    for DCT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DCT gene (2 alternative transcripts): 
    NM_001129889.1  NM_001922.3  

    Unigene Cluster for DCT:

    Dopachrome tautomerase
    Hs.301865  [show with all ESTs]
    Unigene Representative Sequence: AJ000503
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483392 ENST00000377028 ENST00000490854 ENST00000472871 ENST00000446125(uc010afh.3 uc001vlv.4)


    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF339808.1 AJ000503.1 AJ132932.1 AJ132933.1 AK293115.1 BC028311.1 BC104476.1 D17547.1 
    DQ902581.1 L18967.1 S69231.1 

    9 DOTS entries:

    DT.99948931  DT.412293  DT.95374172  DT.95286125  DT.95374169  DT.95374171  DT.100029468  DT.100686319 
    DT.95374176 

    24/166 AceView cDNA sequences (see all 166):

    BU167938 BQ679285 AJ132933 N21337 AA804662 BI494314 BQ893303 BQ678610 
    BQ877690 AA478687 BQ229038 BM461531 NM_001922 AA133791 BM669709 N40084 
    D17547 BU162667 L18967 BF725057 BQ681211 AJ132932 BU166772 BQ427918 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DCT (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                          -     -                 -                       -                     
    SP2:        -     -     -     -     -                 -                                             
    SP3:                          -     -                                                               
    SP4:                                -                                                               
    SP5:                                                  -                                             


    ECgene alternative splicing isoforms for DCT

    Expression
    for DCT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DCT expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinal Pigmented EpitheliumRetinal Pigmented Epithelium Progenitor CellsRetinal Pigmented Epithelium
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    Neural TubeTelencephalonNeural Tube
    Skeletal MuscleExtraocular MusclesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DCT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCT

    SOURCE GeneReport for Unigene cluster: Hs.301865
        SABiosciences Custom PCR Arrays for DCT
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    In Situ
    Assay Products:     
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    Orthologs
    for DCT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for DCT gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DCT1 dopachrome tautomerase (dopachrome delta-isomerase, more 70.91(n)
    69.88(a)    		   395775  NM_204935.1  NP_990266.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DCT6
    		 --
    		 67(a)
    		 1 ↔ 1
    		 3(84712626-84745796)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.125402 Xenopus laevis transcribed sequence with weak similarity more 73.88(n)    CB558792.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dct2 dopachrome tautomerase 72.33(n)   58074  AF280090.1 


    ENSEMBL Gene Tree for DCT (if available)
    TreeFam Gene Tree for DCT (if available) 

    Paralogs
    for DCT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DCT gene
    TYRP12  TYR2  
    3 SIMAP similar genes for DCT using alignment to 3 protein entries:     TYRP2_HUMAN (see all proteins):
    TRP-2    TYRP1    TYR

    DCT for paralogs           About GeneDecksing



    Genomic Variants
    for DCT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/821 NCBI SNPs in DCT are shown (see all 821)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs342410461,2
    		C--75712489(+) CTAAC-/TTTTTT 1 -- int12Minor allele frequency- T:0.25NA 4
    rs95164131,2
    		C,F,A,H,--95091347(+) AGTAGC/TATATC 2 -- ds5001 ese332Minor allele frequency- N:0.00EA NA NS WA CSA 2981
    rs1142290541,2
    		C,--95091361(+) TAACCA/GGGAAA 2 -- ds50010--------
    rs1930987381,2
    		--95091363(+) ACCAGA/GAAACT 2 -- ds50010--------
    rs1429870551,2
    		--95091372(+) CTCTAC/TAATTT 2 -- ds50010--------
    rs1473164061,2
    		--95091400(+) ATCACC/TATAGA 2 -- ds50010--------
    rs412758761,2
    		--95091427(+) CTATTC/GAATCC 2 -- ds50010--------
    rs784076451,2
    		--95091439(+) GTAATA/GTAGGT 2 -- ds50012Minor allele frequency- G:0.19CSA WA 120
    rs1857490931,2
    		--95091505(+) TAGAGC/TGGAAT 2 -- ds50010--------
    rs779135681,2
    		C--95091516(+) TGATCC/GTTCAT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for DCT (95091741 - 95131936 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DCT
         1 CNV: 47869

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    Disorders / Diseases
    for DCT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DCT for disorders           About GeneDecksing

    OMIM gene information: 191275    OMIM disorders: --

    19 diseases for DCT:    About MalaCards
    vogt-koyanagi-harada disease    chediak-higashi syndrome    hermansky-pudlak syndrome    enamel caries
    oculocutaneous albinism    amelanotic melanoma    albinism    malignant glioma
    nevus    microphthalmia    vitiligo    melanoma
    cholera    glioblastoma    stomatitis    retinoblastoma
    retinitis    neuronitis    carcinoma

    10/22 Novoseek disease relationships for DCT gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 82.4 187 9809996 (5), 10897046 (4), 8789739 (4), 9856813 (4) (see all 86)
    melanoma b16 79.3 16 9053445 (2), 10728600 (2), 10078966 (1), 11434569 (1) (see all 10)
    melanoma cloudman s91 77.3 2 10614575 (1)
    vitiligo 75.4 21 9328128 (5), 9856813 (2), 19284502 (2), 16946711 (1) (see all 6)
    microphthalmia 70.7 12 9447965 (2), 8752668 (1), 16197942 (1), 11277492 (1) (see all 7)
    melanoma amelanotic 56.8 1 9877098 (1)
    albinism 35.8 1 8433006 (1)
    tumors 35 28 9053445 (2), 12747770 (2), 12843792 (2), 8976176 (2) (see all 21)
    autoimmunity 34.3 3 12747770 (1), 16185524 (1), 18480980 (1)
    glioblastoma multiforme 27.3 5 17004103 (1), 12843792 (1), 9176405 (1), 9792924 (1)

    Human Genome Epidemiology (HuGE) Navigator: DCT (4 documents)

    Export disorders for DCT gene to outside databases

    Publications
    for DCT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCT gene, integrated from 9 sources (see all 274):
    (articles sorted by number of sources associating them with DCT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells. (PubMed id 8306979)1, 2, 3, 9 Bouchard B.... Dubertret L. (1994)
    2. Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression. (PubMed id 7929451)1, 2, 9 Yokoyama K.... Shibahara S. (1994)
    3. Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy. (PubMed id 11777994)1, 2, 9 Khong H.T. and Rosenberg S.A. (2002)
    4. Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2. (PubMed id 8148378)1, 2, 9 Yokoyama K.... Shibahara S. (1994)
    5. Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. (PubMed id 8530077)1, 2, 9 Sturm R.A.... Dunn I.S. (1995)
    6. Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA. (PubMed id 8206391)1, 2, 9 Cassady J.L. and Sturm R.A. (1994)
    7. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    8. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)1, 2 Basrur V.... Appella E. (2003)

    External Searches for DCT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing DCT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1638 HGNC: 2709 AceView: DCT Ensembl:ENSG00000080166 euGenes: HUgn1638
    ECgene: DCT Kegg: 1638 H-InvDB: DCT

    Other Databases showing DCT gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DCT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCT Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DCT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DCT gene:
    Search GeneIP for patents involving DCT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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