CHSY1 Gene
protein-coding GIFtS: 59
GCID: GC15M101715
|
|
chondroitin sulfate synthase 1(Previous name: carbohydrate (chondroitin) synthase 1 )
| |
Aliases
for CHSY1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chondroitin Sulfate Synthase 11 2 | | Carbohydrate (Chondroitin) Synthase 11 | | CSS11 2 3 | | TPBS2 | | KIAA09901 3 5 | | Carbohydrate Synthase 12 | | Chondroitin Glucuronyltransferase 12 3 | | Chondroitin Glucuronyltransferase II2 | | Chondroitin Synthase 12 3 | | N-Acetylgalactosaminyltransferase II2 | | Glucuronosyl-N-Acetylgalactosaminyl-Proteoglycan4-Beta-N-Acetylgalactosaminyltransferase 12 3 | | EC 2.4.1.1753 | | CHSY2 3 | | EC 2.4.1.2263 | | ChSy-12 3 | | N-Acetylgalactosaminyltransferase 13 | | N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase 12 3 | | |
Export aliases for CHSY1 gene to outside databasesPrevious GC identifers: GC15M098567 GC15M095557 GC15M099308 GC15M099451 GC15M099533 GC15M077838 |
Summaries
for CHSY1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHSY1:
This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dualglucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis ofchondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation andmorphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene area cause of temtamy preaxial brachydactyly syndrome. (provided by RefSeq, Dec 2011)
UniProtKB/Swiss-Prot: CHSS1_HUMAN, Q86X52Function: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfersglucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end ofthe elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation ofNOTCH signaling
Gene Wiki entry for CHSY1
|
Genomic Views
for CHSY1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010274.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHSY1 gene promoter:
AML1a Pax-5 SREBP-1c AP-4 SREBP-1b GATA-2 SRY E2F E2F-1 HSF2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHSY1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHSY1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q26.3 Ensembl cytogenetic band: 15q26.3 HGNC cytogenetic band: 15q26.3CHSY1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M101715: view genomic region
(about GC identifiers)
Start:
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101,715,928 bp from pter |
End:
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101,792,137 bp from pter |
Size:
|
76,210 bases |
Orientation:
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minus strand |
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Proteins
for CHSY1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CHSS1_HUMAN, Q86X52 (See
protein sequence)Recommended Name: Chondroitin sulfate synthase 1 Size: 802 amino acids; 91784 Da
Cofactor: Divalent cations. Highest activities are measured with cobalt, manganese and cadmium
Subunit: Binds CHPF
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (Probable). Secreted
Sequence caution: Sequence=BAA76834.2; Type=Erroneous initiation;
Secondary accessions: Q6UX38 Q7LFU5 Q9Y2J5Explore the universe of human proteins at neXtProt for CHSY1: NX_Q86X52
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86X52
CHSY1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055733.2
ENSEMBL proteins: ENSP00000254190 Reactome Protein details: Q86X52
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CHSY1 for ontologies About GeneDecksing
CHSY1 Antibody Products:
Assay Products for CHSY1: |
Protein
Domains /
Families
for CHSY1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHSY1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86X52ProtoNet protein and cluster: Q86X52 UniProtKB/Swiss-Prot: CHSS1_HUMAN, Q86X52Similarity: Belongs to the chondroitin N-acetylgalactosaminyltransferase family |
Function
for CHSY1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CHSS1_HUMAN, Q86X52Function: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfersglucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end ofthe elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation ofNOTCH signalingCatalytic activity: UDP-N-acetyl-alpha-D-galactosamine +beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP +N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycanCatalytic activity: UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan =UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycanEnzyme Numbers (IUBMB): EC 2.4.1.2261 EC 2.4.1.1751
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHSY1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHSY1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CHSY1 (NM_014918) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHSY1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHSY1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHSY1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- | | GO:0047238 | glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity |
IDA | 11514575 | | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity |
IEA | -- |
CHSY1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CHSY1:
Animal Models:
Mouse knock-out Chsy1tm1Lex for CHSY1
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Chsy1):
CHSY1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CHSY1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | MPS IIIC - Sanfilippo syndrome C | | | 2 | dermatan sulfate biosynthesis | | | 3 | Metabolism | | | 4 | Disease | | | 5 | A tetrasaccharide linker sequence is required for GAG synthesis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4  BioSystems Pathways for CHSY1
5/18 
Reactome Pathways for CHSY1 (see all 18)
2 
Kegg Pathways (Kegg details for CHSY1):
CHSY1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHSY1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/20 Interacting proteins for CHSY1 (ENSP000002541904) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
TAS | -- | | GO:0030203 | glycosaminoglycan metabolic process |
TAS | -- | | GO:0030204 | chondroitin sulfate metabolic process |
TAS | -- | | GO:0030206 | chondroitin sulfate biosynthetic process |
TAS | -- | | GO:0030279 | negative regulation of ossification |
IMP | -- |
CHSY1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CHSY1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CHSY1 for compounds About GeneDecksing
 Browse Tocris compounds for CHSY1
7 HMDB Compounds for CHSY1 About this table
4 Novoseek chemical compound relationships for CHSY1 gene About this table
Search CenterWatch for drugs/clinical trials and news about CHSY1 / CHSS1
|
Transcripts
for CHSY1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHSY1 gene: NM_014918.4 Unigene Cluster for CHSY1: Chondroitin sulfate synthase 1 Hs.110488 [show with all ESTs]Unigene Representative Sequence: BC0462476 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000254190(uc010usd.2 uc021sxt.1) ENST00000543813 ENST00000560766
ENST00000561414 ENST00000561143 ENST00000559384
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHSY1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHSY1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHSY1 (NM_014918) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHSY1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHSY1 |
Additional cDNA sequence: AB023207.1 AB071402.1 AK075096.1 AK296943.1 AL137409.1 AY358529.1 BC046247.1 7 DOTS entries: DT.415599 DT.121075453 DT.100717674 DT.95374360 DT.91687328 DT.95374361 DT.121075473 24/166 AceView cDNA sequences (see all 166): CR604598 AI741626 CA413613 AA864790 AL137409 AA486453 AI476156 AA258809 AA369674 AI741636 AI570770 AI095909 BQ007796 AI608927 BM697629 AA703453 BM767157 AA281496 CK903931 BQ024150 CA445852 Z40893 AA962524 Z45166
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CHSY1 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CHSY1
|
Expression
for CHSY1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHSY1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTTTGGGG
About this image
See CHSY1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHSY1
SOURCE GeneReport for Unigene cluster: Hs.110488
UniProtKB/Swiss-Prot: CHSS1_HUMAN, Q86X52Tissue specificity: Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletalmuscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung andperipheral blood leukocytes
SABiosciences Custom PCR Arrays for CHSY1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHSY1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHSY1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHSY1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHSY1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHSY1 |
Orthologs
for CHSY1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CHSY1 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CHSY11 |
chondroitin sulfate synthase 1 |
82.28(n)
92.53(a) |
|
415521 XM_413889.3 XP_413889.2 |
lizard
(Anolis carolinensis) |
Reptilia |
CHSY16 |
-- |
90(a) |
1 ↔ 1 |
GL343332.1(122207-181705) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.133952 |
Xenopus laevis transcribed sequence with weak similarity more |
80.35(n) |
|
48027170 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.111462 |
Danio rerio cDNA clone MGC64191 IMAGE6798417, complete more |
75.66(n) |
|
BC064670.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG92201 , 3 |
chondroitin sulfate biosynthesis
acetylglucosaminyltransferase3
CG92201 |
41(a)3
54.34(n)1
47.66(a)1 |
|
13D43
324971 NM_206717.21 NP_996440.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
T24D1.13 |
-- |
35(a) |
|
I(9956257-9960794) -- |
ENSEMBL Gene Tree for CHSY1 (if available)
TreeFam Gene Tree for CHSY1 (if available) |
Paralogs
for CHSY1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHSY1 gene
- CSGALNACT12 CHSY32 CHPF2 CSGALNACT22 CHPF22
2 SIMAP similar genes for CHSY1 using alignment to 2 protein entries: CHSS1_HUMAN (see all proteins):CHSY3 ChSy-2
CHSY1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CHSY1
PGOHUM00000242167
|
Genomic Variants
for CHSY1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHSY1 (101715928 - 101792137 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for CHSY1
8 CNVs: 61483 102187 3983 8807 3099 66905 66904 32063
2 Indels: 45396 66903
Human Gene Mutation Database (HGMD): CHSY1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHSY1 |
|
Disorders
/ Diseases
for CHSY1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHSY1 for disorders About GeneDecksing
OMIM gene information: 608183
OMIM disorders: --
UniProtKB/Swiss-Prot: CHSS1_HUMAN, Q86X52
Defects in CHSY1 are the cause of Temtamy preaxial brachydactyly syndrome (TPBS) [MIM:605282]. A syndromecharacterized by multiple congenital anomalies, mental retardation, sensorineural deafness, talon cusps of uppercentral incisors, growth retardation, and bilateral symmetric digital anomalies mainly in the form of preaxialbrachydactyly and hyperphalangism
3  diseases for CHSY1: About MalaCardstemtamy preaxial brachydactyly syndrome brachydactyly colorectal cancer
1 disease from the University of Copenhagen DISEASES database for CHSY1:Brachydactyly Export disorders for CHSY1 gene to outside databases
|
Publications
for CHSY1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHSY1 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with CHSY1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and expression of a human chondroitin synthase. (PubMed id 11514575)1, 2, 3, 9 Kitagawa H.... Sugahara K. (2001)
- Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization. (PubMed id 12716890)1, 2, 9 Kitagawa H.... Sugahara K. (2003)
- Chondroitin sulfate synthase-3. Molecular cloning and characterization. (PubMed id 12907687)1, 2, 9 Yada T....Kimata K. (2003)
- Loss of CHSY1, a secreted FRINGE enzyme, causes syndr omic brachydactyly in humans via increased NOTCH signaling. (PubMed id 21129727)1, 2 Tian J....Reversade B. (2010)
- Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling. (PubMed id 21129728)1, 2 Li Y....Wollnik B. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
- Chondroitin synthases I, II, III and chondroitin sulf ate glucuronyltransferase expression in colorectal cancer. (PubMed id 21468578)1 Kalathas D....Vynios D.H. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for CHSY1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHSY1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHSY1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CHSY1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CHSY1 | Pharmacogenomics, SNPs, Pathways | | GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/ | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_445 |
|
| | |
About This Section
| Patent Information for CHSY1 gene:
Search GeneIP for patents involving CHSY1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CHSY1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CHSY1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHSY1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHSY1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHSY1 | | OriGene 3'-UTR Clone for CHSY1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHSY1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHSY1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHSY1 | | OriGene Custom Protein Services for CHSY1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHSY1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHSY1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHSY1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHSY1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHSY1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHSY1 |
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| | | | Search Tocris compounds for CHSY1 |
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 | | | CHSY1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHSY1 |
|  |  |  | | | | Search ThermoFisher Antibodies for CHSY1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHSY1 |
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