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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDO1 Gene

protein-coding   GIFtS: 63
GCID: GC05M115168

cysteine dioxygenase, type I
 Explore 4 diseases affiliated with
CDO1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDO1    

Aliases
for CDO1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cysteine Dioxygenase, Type I1 2
CDO2 3
CDO-I2 3
EC 1.13.11.203 8
Cysteine Dioxygenase Type 12
Cysteine Dioxygenase Type I3

External Ids:    HGNC: 17951   Entrez Gene: 10362   Ensembl: ENSG000001295967   OMIM: 6039435   UniProtKB: Q168783   

Export aliases for CDO1 gene to outside databases

Previous GC identifers: GC05M114908 GC05M115547 GC05M115171 GC05M115216 GC05M110321


Summaries
for CDO1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CDO1_HUMAN, Q16878
Function: Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including
sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in
maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range




Genomic Views
for CDO1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDO1 gene promoter:
         POU2F2 (Oct-2.1)   oct-B3   oct-B2   FOXD1   POU2F2   Evi-1   POU2F1   POU2F1a   c-Myb   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2   Ensembl cytogenetic band:  5q22.3   HGNC cytogenetic band: 5q23.2

CDO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDO1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M115168:  view genomic region     (about GC identifiers)

Start:
 115,140,430 bp from pter      End:
 115,152,651 bp from pter
Size:
 12,222 bases      Orientation:
 minus strand

Proteins
for CDO1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDO1_HUMAN, Q16878 (See protein sequence)
Recommended Name: Cysteine dioxygenase type 1  
Size: 200 amino acids; 22972 Da
Cofactor: Binds 1 iron ion per subunit. Zinc to a much lesser extent
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for CDO1:
2IC1 (3D)    
Secondary accessions: B2RAK4 P78513 Q6FHZ8 Q8TB64

Explore the universe of human proteins at neXtProt for CDO1: NX_Q16878

Post-translational modifications:

  • The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and
    • prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16878

    • 4/6 DME Specific Peptides for CDO1 (Q16878) (see all 6)
     FDQRTGH  YTRNLVD  TFHSKFG  NLMILCWG 

    CDO1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001792.2  
    ENSEMBL proteins: 
     ENSP00000250535  
    Reactome Protein details: Q16878
    Human Recombinant Protein Products: 
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    Novus Biologicals CDO1 Proteins
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    ProSpec Recombinant Protein for CDO1
    Uscn Proteins for CDO1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    CDO1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CDO1

    Protein Domains /
    Families
    for CDO1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDO1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011051 RmlC_Cupin
     IPR010300 Cys_dOase_I
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q16878

    ProtoNet protein and cluster: Q16878

    1 Blocks protein family: IPB010300 Cysteine dioxygenase type I

    UniProtKB/Swiss-Prot: CDO1_HUMAN, Q16878
    Similarity: Belongs to the cysteine dioxygenase family


    Function
    for CDO1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDO1_HUMAN, Q16878
    Function: Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including
    sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in
    maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range
    Catalytic activity: L-cysteine + O(2) = 3-sulfinoalanine
    Induction: In hepatoblastoma Hep-G2 cells, down-regulated by phorbol 12-myristate 13-acetate (PMA)

         Genatlas biochemistry entry for CDO1:
    cysteine dioxygenase-1,cytosolic,expressed in liver

    Enzyme Number (IUBMB): EC 1.13.11.201 2

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CDO1:
    hsa-miR-607
    SwitchGear 3'UTR luciferase reporter plasmid: CDO1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008198ferrous iron binding IEA--
    GO:0017172cysteine dioxygenase activity TAS--


    CDO1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CDO1:
     Increased G1 DNA content  Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-out Cdo1tm1.1Mhst for CDO1
         13 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cdo1):
     behavior/neurological  cardiovascular system  craniofacial  endocrine/exocrine gland  growth/size 
     hearing/vestibular/ear  homeostasis/metabolism  limbs/digits/tail  mortality/aging  reproductive system 
     respiratory system  skeleton  vision/eye 

    CDO1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDO1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sulfur amino acid metabolism
    		Sulfur amino acid metabolism1.00
    		Cysteine and methionine metabolism0.36
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3Transcription CREB pathway
    		Transcription CREB pathway1.00
    		Transcription_CREB pathway0.93
    4L-cysteine degradation I
    		L-cysteine degradation I1.00
    		taurine biosynthesis0.33
    5Metabolism of amino acids and derivatives
    		Metabolism of amino acids and derivatives1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CDO1
        Transcription CREB pathway


    1 GeneGo (Thomson Reuters) Pathway for CDO1
        Transcription CREB pathway

    3 BioSystems Pathways for CDO1 
        taurine biosynthesis
    superpathway of methionine degradation
    L-cysteine degradation I

    4        Reactome Pathways for CDO1
        Metabolism
    Sulfur amino acid metabolism
    Degradation of cysteine and homocysteine
    Metabolism of amino acids and derivatives


    3         Kegg Pathways  (Kegg details for CDO1):
        Cysteine and methionine metabolism
    Taurine and hypotaurine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: CDO1_HUMAN, Q16878
    Pathway: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2


    CDO1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/16 Interacting proteins for CDO1 (Q168783 ENSP000002505354) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    VHLP403373, ENSP000002564744I2D: score=1 STRING: ENSP00000256474
    MAPK14Q165393I2D: score=1 
    SPAG9O602713I2D: score=1 
    CSADENSP000002670854STRING: ENSP00000267085
    CTHENSP000003599764STRING: ENSP00000359976
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0000097sulfur amino acid biosynthetic process TAS12110289
    GO:0000098sulfur amino acid catabolic process TAS--
    GO:0006534cysteine metabolic process TAS12110289
    GO:0006954inflammatory response TAS12110289


    CDO1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDO1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDO1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDO1

    5 HMDB Compounds for CDO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Sulfinoalanine3-Sulphino-L-alanine (see all 9)1115-65-7--
    IronArmco iron (see all 19)7439-89-6--
    L-Cysteine(+)-2-Amino-3-mercaptopropionic acid (see all 37)52-90-4--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OxygenOxygen (see all 5)7782-44-7--

    2 DrugBank Compounds for CDO1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Cysteine(R)-2-Amino-3-mercaptopropanoic acid (see all 13)52-90-4target--17135237 16492780 16355974 17657274
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    5 Novoseek chemical compound relationships for CDO1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine sulfinic acid 93.1 8 18308719 (1), 10936171 (1), 19011731 (1), 11008216 (1) (see all 7)
    taurine 76.4 16 12871209 (3), 10936171 (2), 14553911 (1), 11008216 (1) (see all 7)
    cysteine 73.9 73 14644768 (5), 17327371 (4), 19011731 (3), 11101006 (3) (see all 22)
    sulfate 47.8 4 18308719 (1), 11101006 (1), 14514920 (1)
    oligonucleotide 15.2 3 8835096 (1), 14514920 (1)

    Search CenterWatch for drugs/clinical trials and news about CDO1 

    Transcripts
    for CDO1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDO1 gene: 
    NM_001801.2  

    Unigene Cluster for CDO1:

    Cysteine dioxygenase, type I
    Hs.442378  [show with all ESTs]
    Unigene Representative Sequence: NM_001801
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250535(uc003krg.3) ENST00000502631 ENST00000504877 ENST00000504613


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    hsa-miR-607
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK130357.1 AK314231.1 BC024241.2 CR536540.1 D85777.1 Z23010.1 Z31357.1 

    9 DOTS entries:

    DT.216274  DT.100693226  DT.101978494  DT.100798407  DT.100798408  DT.100737449  DT.101957002  DT.91718020 
    DT.92427054 

    24/179 AceView cDNA sequences (see all 179):

    CR607883 BQ446328 CR598067 AI744535 CB163882 BM707344 CR591921 R63381 
    AV703068 CR536540 N39918 BU688469 BM718652 D85777 AI049893 BM668774 
    AU117783 BQ182119 CR606190 BU742330 AI129218 BQ637817 BG565556 CA397470 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CDO1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:              -     -                                                         
    SP2:                    -                             -                           
    SP3:                                -                 -                           
    SP4:                    -                                                         
    SP5:                                                                              


    ECgene alternative splicing isoforms for CDO1

    Expression
    for CDO1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCATAGTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDO1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    AdiposeVisceral White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CDO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDO1

    SOURCE GeneReport for Unigene cluster: Hs.442378

    UniProtKB/Swiss-Prot: CDO1_HUMAN, Q16878
    Tissue specificity: Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected
    in hepatoblastoma Hep-G2 cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDO1: 
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              Neurotoxicity in human mouse rat

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    In Situ
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    Orthologs
    for CDO1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CDO1 gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cdo11 , 5 cysteine dioxygenase 1, cytosolic1, 5 87.33(n)1
    92(a)1    		   18 (24.75 cM)5
    125831  NM_033037.31  NP_149026.11 
     467132055 
    chicken
    (Gallus gallus)    		 Aves CDO11 cysteine dioxygenase, type I 75.25(n)
    78.79(a)    		   427391  XM_424964.2  XP_424964.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CDO16
    		 --
    		 77(a)
    		 1 ↔ 1
    		 GL343193.1(8361216-8377251)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC686562 hypothetical protein MGC68656 77.32(n)    BC060414.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc731812 hypothetical protein MGC73181 74.28(n)   393714  BC059531.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG54931 , 3 cysteine dioxygenase3
    CG54931    		 52(a)3
    59.18(n)1
    57.3(a)1    		   55E23
    371391  NM_137504.21  NP_611348.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea F56F10.33
    cdo-11    		 cytenine dioxygenase3
    Protein CDO-11    		 50(a)3
    56.44(n)1
    50(a)1    		   X(897348-899507)3
    1804341  NM_075767.21  NP_508168.11 


    ENSEMBL Gene Tree for CDO1 (if available)
    TreeFam Gene Tree for CDO1 (if available) 

    Paralogs
    for CDO1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CDO1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/265 NCBI SNPs in CDO1 are shown (see all 265)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1441171221,2
    		--115139947(+) CACTTC/TGGGAG 1 -- int10--------
    rs1164069771,2
    		F,--115139984(+) GGAGAT/CCGAGA 1 -- int11Minor allele frequency- C:0.04WA 118
    rs1486993021,2
    		--115139986(+) AGATCA/GAGACC 1 -- int10--------
    rs1382522191,2
    		--115140011(+) CCCCG-/TCTCTAC 1 -- int10--------
    rs1422278381,2
    		--115140143(+) ACCCCA/GTCTCT 1 -- int10--------
    rs1843217151,2
    		--115140215(+) GAGGCC/TGAGGC 1 -- int10--------
    rs1900354821,2
    		--115140264(+) GAGCCA/GAGATT 1 -- int10--------
    rs357578541,2
    		C--115140315(+) AAAAA-/ACCATT 1 -- int12Minor allele frequency- A:0.25NA 4
    rs100627581,2
    		C--115140317(+) ctcaaC/Aaaaaa 1 -- int11Minor allele frequency- A:0.50WA 2
    rs732596081,2
    		C,--115140411(+) GTTAAT/ACAGAA 1 -- int12Minor allele frequency- A:0.07WA 120

    HapMap Linkage Disequilibrium report for CDO1 (115140430 - 115152651 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CDO1
         2 CNVs: 93199 81016

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    Disorders / Diseases
    for CDO1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDO1 for disorders           About GeneDecksing

    OMIM gene information: 603943    OMIM disorders: --

    4 diseases for CDO1:    About MalaCards
    cutaneous t cell lymphoma    hepatoblastoma    breast cancer    hepatitis

    3 Novoseek disease relationships for CDO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatoblastoma 54.4 2 10427686 (1), 12871209 (1)
    necrosis 0 2 11101006 (1)
    tumors 0 2 11101006 (1)


    Export disorders for CDO1 gene to outside databases

    Publications
    for CDO1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDO1 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with CDO1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. (PubMed id 7524679)1, 2, 3, 9 McCann K.P.... Ramsden D.B. (1994)
    2. Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene. (PubMed id 9497919)1, 2, 9 Ramsden D.B....Williams A.C. (1997)
    3. An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. (PubMed id 17135237)2, 7 Ye S.... Rao Z. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Development of an in vitro model for cysteine dioxygenase expression in the brain. (PubMed id 11101006)1, 9 Qusti S....Ramsden D.B. (2000)
    6. Human cysteine dioxygenase gene: structural organization, tissue- specific expression and downregulation by phorbol 12-myristate 13- acetate. (PubMed id 10427686)2, 9 Tsuboyama-Kasaoka N....Totani M. (1999)
    7. Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells. (PubMed id 17327371)1, 9 Dominy J.E....Stipanuk M.H. (2007)
    8. Functional characterization and regulation of the taurine transporter and cysteine dioxygenase in human hepatoblastoma HepG2 cells. (PubMed id 12871209)1, 9 Satsu H....Shimizu M. (2003)
    9. Why do cysteine dioxygenase enzymes contain a 3-His l igand motif rather than a 2His/1Asp motif like most nonheme dioxygenases? (PubMed id 19199799)1, 9 de Visser S.P. and Straganz G.D. (2009)
    10. Structure and mechanism of mouse cysteine dioxygenase. (PubMed id 16492780)7, 9 McCoy J.G....Phillips G.N. (2006)

    External Searches for CDO1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing CDO1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1036 HGNC: 1795 AceView: CDO1 Ensembl:ENSG00000129596 euGenes: HUgn1036
    ECgene: CDO1 Kegg: 1036 H-InvDB: CDO1

    Other Databases showing CDO1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDO1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDO1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CDO1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDO1 gene:
    Search GeneIP for patents involving CDO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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