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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD44 Gene

protein-coding   GIFtS: 70
GCID: GC11P035116

CD44 molecule (Indian blood group)

(Previous name: CD44 antigen (homing function and Indian blood group system)...)
(Previous symbols: MIC4, MDU2, MDU3)
 Explore 223 diseases affiliated with
CD44 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD44    

Aliases
for CD44 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD44 Molecule (Indian Blood Group)1 2     CD44 Antigen2 3
MDU21 2 3 5     GP90 Lymphocyte Homing/Adhesion Receptor2 3
MDU31 2 3 5     Hermes Antigen2 3
MIC41 2 3 5     CD44R1
CSPG81 2     CD44 Antigen (Homing Function And Indian Blood Group System)1
HCELL1 2     CDW442
IN1 2     Cell Surface Glycoprotein CD442
MC561 2     Chondroitin Sulfate Proteoglycan 82
Pgp11 2     Epican3
Extracellular Matrix Receptor III2 3     Hematopoietic Cell E- And L-Selectin Ligand2
Heparan Sulfate Proteoglycan2 3     Homing Function And Indian Blood Group System2
Hyaluronate Receptor2 3     CDw443
Phagocytic Glycoprotein 12 3     Epican3
ECMR-III2 3     PGP-13
HUTCH-I2 3     PGP-I3
LHR2 3     Phagocytic Glycoprotein I3

External Ids:    HGNC: 16811   Entrez Gene: 9602   Ensembl: ENSG000000265087   OMIM: 1072695   UniProtKB: P160703   

Export aliases for CD44 gene to outside databases

Previous GC identifers: GC11P036713 GC11P035838 GC11P035199 GC11P035124 GC11P035125 GC11P034858


Summaries
for CD44 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD44:
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and
migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin,
collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions
including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this
gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full
length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural
and functional diversity of this protein, and may be related to tumor metastasis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD44_HUMAN, P16070
Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for
HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix
metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression.
Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or
dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing
and post-translational modification events

Gene Wiki entry for CD44


Genomic Views
for CD44 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD44 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD44 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD44

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD44


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

CD44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD44 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P035116:  view genomic region     (about GC identifiers)

Start:
 35,160,417 bp from pter      End:
 35,253,949 bp from pter
Size:
 93,533 bases      Orientation:
 plus strand

Proteins
for CD44 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD44_HUMAN, P16070 (See protein sequence)
Recommended Name: CD44 antigen precursor  
Size: 742 amino acids; 81538 Da
Subunit: Interacts with PKN2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen,
laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2
via its C-terminal segment
Subcellular location: Membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane
protrusions at wounding edges (By similarity)
3 PDB 3D structures from and Proteopedia for CD44:
1POZ (3D)        1UUH (3D)        2I83 (3D)    
Secondary accessions: A5YRN9 B6EAT9 D3DR12 D3DR13 O95370 P22511 Q04858 Q13419 Q13957 Q13958 Q13959
Q13960 Q13961 Q13967 Q13968 Q13980 Q15861 Q16064 Q16065 Q16066 Q16208 Q16522 Q86T72 Q86Z27 Q8N694
Q92493 Q96J24 Q9H5A5 Q9UC28 Q9UC29 Q9UC30 Q9UCB0 Q9UJ36
Alternative splicing: 19 isoforms:  P16070-1   P16070-2   P16070-3   P16070-4   P16070-5   P16070-6   P16070-7   P16070-8   
P16070-9   P16070-10   P16070-11   P16070-12   P16070-13   P16070-14   P16070-15   P16070-16   
P16070-17   P16070-18   P16070-19   (Soluble isoform, has enhanced hyaluronan binding)

Explore the universe of human proteins at neXtProt for CD44: NX_P16070

Post-translational modifications:

  • Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and
    • tumors1
  • N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may
    • affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs
    on Thr-637 or Thr-6381
  • Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and
    • the phosphorylation of Ser-6721
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P16070

    • CD44 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (8 alternative transcripts): 
    NP_000601.3  NP_001001389.1  NP_001001390.1  NP_001001391.1  NP_001001392.1  NP_001189484.1  NP_001189485.1  NP_001189486.1  

    ENSEMBL proteins: 
     ENSP00000263398   ENSP00000435377   ENSP00000389830   ENSP00000398632   ENSP00000395953  
     ENSP00000392331   ENSP00000278386   ENSP00000404447   ENSP00000309732   ENSP00000398099  
     ENSP00000432405   ENSP00000432704   ENSP00000434465   ENSP00000279452   ENSP00000434530  
     ENSP00000432718   ENSP00000433189   ENSP00000436549   ENSP00000436623   ENSP00000436980  
     ENSP00000278385   ENSP00000435321   ENSP00000436451   ENSP00000434418   ENSP00000431860  
     ENSP00000434920   ENSP00000414567   ENSP00000391008   ENSP00000403990   ENSP00000353280  
    Reactome Protein details: P16070
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD44
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): CD44
    OriGene Protein Over-expression Lysate (see all 4): CD44
    OriGene Custom Protein Services for CD44 
    GenScript Custom Purified and Recombinant Proteins Services for CD44
    Novus Biologicals CD44 Proteins
    Novus Biologicals CD44 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS1991450
    GO:0009897external side of plasma membrane IEA--


    CD44 for ontologies           About GeneDecksing



    CD44 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD44
    R&D Systems Antibodies for CD44
    Cell Signaling Technology (CST) Antibodies for CD44 
    OriGene Antibodies (see all 3): CD44
    OriGene Custom Antibody Services for CD44 
    GenScript Custom Superior Antibodies Services for CD44
    Novus Biologicals CD44 Antibodies
    Abcam antibodies for CD44 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for CD44

    Assay Products for CD44: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Multiplex/Array Assay Kits & Reagents for CD44
    GenScript Custom Assay Services for CD44
    Enzo Life Sciences assays for CD44
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CD44 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD44 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000538 Link
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001231 CD44_antigen

    Graphical View of Domain Structure for InterPro Entry P16070

    ProtoNet protein and cluster: P16070

    2 Blocks protein families:
    IPB000538 Link domain
    IPB001231 CD44 antigen precursor signature


    UniProtKB/Swiss-Prot: CD44_HUMAN, P16070
    Domain: The lectin-like LINK domain is responsible for hyaluronan binding (By similarity)
    Similarity: Contains 1 Link domain


    Function
    for CD44 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD44_HUMAN, P16070
    Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for
    HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix
    metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression.
    Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or
    dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing
    and post-translational modification events

         Genatlas biochemistry entry for CD44:
    cell differentiation antigen CD44 (Pgp-1),80-95kDa,identified by antibodies GRHL1,F10-44-2 (including MDU2,MDU3,MIC4
    identified by monoclonal antibodies A1G3,13D8,F10.44),lymphocyte homing receptor,involved in extracellular matrix
    adhesion and in myeloid differentiation,expressed in small lymphocytic and mantle cell lymphoma,on leukemic blasts
    from most AML patients,and in invasive basal cell carcinomas

    miRNA
    Products:            		miRTarBase miRNAs that target CD44:
    hsa-mir-608 (MIRT005967), hsa-mir-34a (MIRT005480), hsa-mir-199a-3p (MIRT003790), hsa-mir-373 (MIRT002428), hsa-mir-520c-3p (MIRT004082), hsa-mir-216a (MIRT005969), hsa-mir-330-3p (MIRT005968), hsa-mir-328 (MIRT000989)

    OriGene 3'-UTR Clone (see all 5): CD44
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD44
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate CD44 (see all 62):
    hsa-miR-579 hsa-miR-3164 hsa-miR-548j hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-3146
    SwitchGear 3'UTR luciferase reporter plasmid: CD44 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD44 (see all 7)
    OriGene shRNA RFP: CD44
    OriGene siRNA: CD44
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD44

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD44

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD44 (see all 12)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD44 (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 8): CD44 (NM_001202555)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD44
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD44 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CD44
    Search LifeMap BioReagents cell lines for CD44

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD44

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004415hyalurononglucosaminidase activity IDA17170110
    GO:0004888contributes to transmembrane signaling receptor activity IDA17045821
    GO:0005515protein binding IPI--
    GO:0005518collagen binding NAS2471973
    GO:0005540hyaluronic acid binding NAS1991450


    CD44 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CD44:
     Decreased focal adhesion (FA)  

    Animal Models:
         Mouse knock-outs for CD44: Cd44tm2.1Ugu Cd44tm1.1Ugu Cd44tm2Kmz Cd44tm1Mak Cd44tm1Ugu
         15/23 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Cd44) (see all 23):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  nervous system 

    CD44 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CD44 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/14 pathways (see all 14)
    		MPS VI - Maroteaux-Lamy syndrome1.00
    		MPS VII - Sly syndrome1.00
    		MPS IIIC - Sanfilippo syndrome C1.00
    		MPS IIIA - Sanfilippo syndrome A1.00
    		MPS I - Hurler syndrome1.00
    		MPS IIID - Sanfilippo syndrome D1.00
    		Mucopolysaccharidoses1.00
    		MPS IX - Natowicz syndrome1.00
    2Hyaluronan uptake and degradation
    		Hyaluronan uptake and degradation1.00
    		Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments0.60
    		Hyaluronan metabolism0.71
    3Cell adhesion_Cell-matrix glycoconjugates
    		Cell adhesion_Cell-matrix glycoconjugates1.00
    		Cell adhesion Cell-matrix glycoconjugates0.97
    4Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    5Interferon gamma signaling
    		Interferon gamma signaling1.00
    		Expression of IFNG-stimulated genes0.72

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for CD44
        Development Beta-adrenergic receptors regulation of ERK
    Cell adhesion Cell-matrix glycoconjugates
    Signal transduction Calcium signaling
    Cell adhesion ECM remodeling

    1 R&D Systems Pathway for CD44
        Articular Cartilage Extracellular Matrix

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD44
        Rac1 Pathway
    Glioma Invasiveness

    2 Cell Signaling Technology (CST) Pathways for CD44
        Lymphocyte Signaling
    Adhesion

    4 GeneGo (Thomson Reuters) Pathways for CD44
        Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion ECM remodeling
    Development Beta-adrenergic receptors regulation of ERK
    Signal transduction Calcium signaling

    5 BioSystems Pathways for CD44 
        Wnt Signaling Pathway and Pluripotency
    Senescence and Autophagy
    TGF-beta Receptor Signaling Pathway
    Paxillin-independent events mediated by a4b1 and a4b7
    Osteopontin-mediated events

    5/24        Reactome Pathways for CD44 (see all 24)
        Hyaluronan metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    MPS IIIA - Sanfilippo syndrome A


    3         Kegg Pathways  (Kegg details for CD44):
        ECM-receptor interaction
    Hematopoietic cell lineage
    Shigellosis


    CD44 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD44

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/143 Interacting proteins for CD44 (P160701, 3 ENSP000002783854) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC7A11Q9UPY51, 3, ENSP000002806124EBI-490245,EBI-3843348 I2D: score=1 STRING: ENSP00000280612
    HBEGFQ990753, ENSP000002309904I2D: score=3 STRING: ENSP00000230990
    LCKP062393, ENSP000003378254I2D: score=3 STRING: ENSP00000337825
    MMP7P092373, ENSP000002602274I2D: score=3 STRING: ENSP00000260227
    NF2P352403, ENSP000003446664I2D: score=3 STRING: ENSP00000344666
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0002246wound healing involved in inflammatory response IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007155cell adhesion ----
    GO:0007160cell-matrix adhesion NAS1922057


    CD44 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD44 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD44 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD44

    1 HMDB Compound for CD44    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronic acidhyaluronic acid 9004-61-9--

    1 DrugBank Compound for CD44    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    HyaluronanHyaluronate (see all 4)9067-32-7target----

    10/98 Novoseek chemical compound relationships for CD44 gene (see all 98)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 84 381 15828943 (7), 17076095 (7), 11721159 (6), 9634638 (5) (see all 99)
    glycosaminoglycan 70.9 35 9298694 (3), 7504022 (1), 7515731 (1), 9058710 (1) (see all 28)
    chondroitin sulfate 59.1 66 10950950 (6), 9891023 (4), 8546427 (2), 8752662 (2) (see all 25)
    matrigel 52.9 11 1906507 (2), 19724912 (2), 7518347 (2), 9815853 (1) (see all 7)
    heparan sulfate 47.5 46 7532176 (7), 9891023 (4), 10950950 (2), 10583162 (2) (see all 16)
    paraffin 46.1 19 15867228 (1), 9666819 (1), 9833394 (1), 10550296 (1) (see all 18)
    slex 35.4 7 9430509 (2), 8547121 (1), 19651422 (1), 8838015 (1)
    vegf 29.5 45 19638429 (5), 20073217 (3), 9893599 (3), 19017033 (2) (see all 25)
    chondroitin 29.3 10 10950950 (3), 9334256 (1), 11821431 (1), 10222064 (1) (see all 6)
    tunicamycin 28.7 3 8601595 (1), 10714394 (1), 9111868 (1)

    Search CenterWatch for drugs/clinical trials and news about CD44 

    Transcripts
    for CD44 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD44 gene (8 alternative transcripts): 
    NM_000610.3  NM_001001389.1  NM_001001390.1  NM_001001391.1  NM_001001392.1  NM_001202555.1  NM_001202556.1  NM_001202557.1  

    Unigene Cluster for CD44:

    CD44 molecule (Indian blood group)
    Hs.502328  [show with all ESTs]
    Unigene Representative Sequence: NM_000610
    18/42 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 42):
    ENST00000263398(uc001mvu.3 uc001mvv.3 uc001mvw.3 uc001mwc.4 uc001mvx.3 uc010rer.2 uc001mvy.3 uc009ykh.3)
    ENST00000526025 ENST00000415148 ENST00000528086 ENST00000428726 ENST00000425428
    ENST00000433892(uc010ret.2) ENST00000278386 ENST00000434472 ENST00000352818
    ENST00000442151(uc021qfw.1) ENST00000525211 ENST00000526669 ENST00000526000
    ENST00000279452 ENST00000527889 ENST00000531118 ENST00000528455

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 5): CD44
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD44
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate CD44 (see all 62):
    hsa-miR-579 hsa-miR-3164 hsa-miR-548j hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-3146
    SwitchGear 3'UTR luciferase reporter plasmid: CD44 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD44 (see all 7)
    OriGene shRNA RFP: CD44
    OriGene siRNA: CD44
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD44
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD44 (see all 12)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD44 (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 8): CD44 (NM_001202555)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD44
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD44 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD44
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD44
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD44
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD44

    Additional cDNA sequence: 

    AB073901.1 AF098641.1 AJ251595.1 AK127622.1 AK129808.1 AK290424.1 AK297776.1 AK304467.1 
    AK307707.1 AL832642.2 AY101192.1 AY101193.1 BC004372.1 BC052287.1 BC067348.1 D28447.1 
    EF581837.1 FJ216964.1 M24915.1 M25078.1 M59040.1 M83324.1 M83325.1 M83326.1 
    M83327.1 M83328.1 S66400.1 S82326.1 U40373.1 U94902.1 U94903.1 X55150.1 
    X55938.1 X56794.1 X62739.1 X66733.1 

    24/48 DOTS entries (see all 48):

    DT.100684183  DT.97864832  DT.91789386  DT.95300618  DT.95300704  DT.100684179  DT.92461255  DT.100684175 
    DT.100684181  DT.87016134  DT.450200  DT.95300655  DT.100735366  DT.120740562  DT.120740539  DT.100664096 
    DT.100684170  DT.75143398  DT.40113924  DT.40129290  DT.86843055  DT.95300681  DT.120740557  DT.120740587 

    24/1216 AceView cDNA sequences (see all 1216):

    BQ004566 BM742678 BU184888 CB124471 BP363182 AA305039 M83324 BM788191 
    BQ720761 CB120042 AA361671 BM766330 BM781491 AI292234 AA382096 BG680436 
    AA523003 BM799113 AA613095 CB138883 CA946461 NM_001001389 BM850850 AI369195 

    GeneLoc Exon Structure

    5/33 Alternative Splicing Database (ASD) splice patterns (SP) for CD44 (see all 33)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
    SP1:                                                                                                                                      -           -     -   
    SP2:                                                                                                                                      -     -     -     -   
    SP3:                                                                                                                                      -     -     -     -   
    SP4:                                                                                                                                      -     -     -     -   
    SP5:                                                                                                                                      -     -     -     -   

    ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a ·
    SP1:  -           -     -           -                                         -     -     -                                                     -               
    SP2:  -           -     -           -                                         -     -     -                                                     -               
    SP3:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                         -               
    SP4:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -               
    SP5:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -               

    ExUns: 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26a · 26b · 26c
    SP1:                                -                     
    SP2:                                -                     
    SP3:                                -                     
    SP4:                                -                     
    SP5:                                                      


    ECgene alternative splicing isoforms for CD44

    Expression
    for CD44 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD44 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGATTGGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CD44 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/23 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 23) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Lateral Plate MesodermAorta-Gonad-MesonephrosHematopoietic Stem CellsBlood
    LiverLiver BudHematopoietic Stem CellsBlood
    BoneAutopod PerichondriumEndochondral PreosteoblastsBone
    BoneCervical VertebraeEndochondral PreosteoblastsBone
    BoneLumbar VertebraeEndochondral PreosteoblastsBone
    BoneSacral VertebraeEndochondral PreosteoblastsBone
    BoneStylopod PerichondriumEndochondral PreosteoblastsBone
    BoneThoracic RibEndochondral PreosteoblastsBone
    BoneThoracic VertebraeEndochondral PreosteoblastsBone
    BoneZeugopod PerichondriumEndochondral PreosteoblastsBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/23 LifeMap Cells (see all 23) 
    NameCategory
    Human multipotent adipose-derived (hMAD) stem cells (Adult Stem / Progenitor Cell)Adipose
    Adipose-derived mesenchymal stem cells (Adult Stem / Progenitor Cell)Adipose
    Bone marrow-derived adherent progenitor cells (MultiStem) (Adult Stem / Progenitor Cell)Bone
    Bone marrow-derived mesenchymal stem cells (Lonza) (Adult Stem / Progenitor Cell)Bone
    Human bone marrow-derived mesenchymal stem cells (Adult Stem / Progenitor Cell)Bone
    Parietal epithelial cells (PEC) (Adult Stem / Progenitor Cell)Epithelium, Kidney
    Adult human kidney epithelial cells (Primary Cell)Kidney
    Endometrial regenerative cell (Adult Stem / Progenitor Cell)Reproductive System
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

    See CD44 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD44

    SOURCE GeneReport for Unigene cluster: Hs.502328

    UniProtKB/Swiss-Prot: CD44_HUMAN, P16070
    Tissue specificity: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by
    carcinomas. Expression is repressed in neuroblastoma cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD44 (see all 17): 
              Parkinson's Disease in human mouse rat
              HIV Host Response in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Multiple Sclerosis in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD44
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD44
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD44

    Orthologs
    for CD44 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CD44 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cd441 , 5 CD44 antigen1, 5 79.44(n)1
    71.47(a)1    		   2 (54.13 cM)5
    125051  NM_009851.21  NP_033981.21 
     1028111415 
    chicken
    (Gallus gallus)    		 Aves CD441 CD44 molecule (Indian blood group) 60.48(n)
    54.72(a)    		   395666  NM_204860.2  NP_990191.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CD446
    		 --
    		 42(a)
    		 1 ↔ 1
    		 1(54805519-54854221)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CD361163.12   -- 70.78(n)    CD361163.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003308011 uncharacterized LOC100330801 50.4(n)
    36.14(a)    		   100330801  XM_002666970.1  XP_002667016.1 


    ENSEMBL Gene Tree for CD44 (if available)
    TreeFam Gene Tree for CD44 (if available) 

    Paralogs
    for CD44 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD44 gene
    LYVE12  

    CD44 for paralogs           About GeneDecksing



    Genomic Variants
    for CD44 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CD44_HUMAN, P16070
    Polymorphism: CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2
    blood group antigens is a single variation in position 46; In(B), the most frequent allele, has Arg-46


    10/2492 NCBI SNPs in CD44 are shown (see all 2492)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs752188721,2
    		C,F,--34856991(+) TCACAT/CTGCTC 9 -- us2k1 int11Minor allele frequency- C:0.10WA 118
    rs1133543721,2
    		--34857329(+) TGTTCG/ATCACT 9 -- us2k1 int11Minor allele frequency- A:0.50CSA 2
    rs734536231,2
    		C,--34857357(+) GATGAC/GTTACT 9 -- int1 us2k12Minor allele frequency- G:0.05WA 120
    rs784083801,2
    		--34857410(+) TTGAGG/TCCTGC 9 -- int1 us2k11Minor allele frequency- T:0.01WA 118
    rs613276741,2
    		--34857613(+) TACCTC/TGATAC 9 -- int1 us2k10--------
    rs1128381491,2
    		--34857742(+) CTGGCA/GTGGTT 9 -- us2k1 nc-transcript-variant2Minor allele frequency- G:0.03CSA WA 120
    rs571872601,2
    		C,--34857800(+) AACTC-/ACCAGG 9 -- nc-transcript-variantus2k10--------
    rs79444091,2
    		C,F,H,--34857830(+) TACTTT/GTAGTA 9 -- us2k1 nc-transcript-variant11Minor allele frequency- G:0.06NS EA NA WA CSA 1214
    rs610566801,2
    		C,--34857904(+) AGATAT/CAGAGT 9 -- nc-transcript-variantus2k12Minor allele frequency- C:0.11WA 120
    rs767490231,2
    		F,--34858668(+) CCCACC/ACCTCA 9 -- us2k11Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for CD44 (35160417 - 35253949 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CD44
         3 CNVs: 85721 3844 2918
    Human Gene Mutation Database (HGMD): CD44
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing CD44:
    Oncogenes & Tumor Suppressor Genes 384HC
    Gastric Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD44
    DNA2.0 Custom Variant and Variant Library Synthesis for CD44

    Disorders / Diseases
    for CD44 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD44 for disorders           About GeneDecksing

    OMIM gene information: 107269    OMIM disorders: --

    20/223 diseases for CD44 (see all 223):    About MalaCards
    malignant peripheral nerve sheath tumor    spinal cord astrocytoma    diffuse large b-cell lymphoma    human t-cell leukemia virus type 1
    hypersensitivity reaction type ii disease    hematopoiesis    lichen sclerosus    gliomatosis cerebri
    wiskott-aldrich syndrome    squamous cell carcinoma    non-small cell lung carcinoma    lichen planus
    b-cell lymphomas    nonpapillary renal cell carcinoma    laryngeal squamous cell carcinoma    follicular mucinosis
    dry eye syndrome    dyserythropoietic anemia    smooth muscle tumor    oral lichen planus

    14 diseases from the University of Copenhagen DISEASES database for CD44:
    Carcinoma     Breast cancer     Colorectal cancer     Prostate cancer
    Leukemia     Lymphoma     Arthritis     Pancreatic cancer
    Melanoma     Ovarian cancer     Malignant glioma     Hypersensitivity reaction type II disease
    Lung cancer     Kidney disease

    10/94 Novoseek disease relationships for CD44 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 78.3 546 11005492 (8), 9772282 (5), 11582589 (5), 17912438 (4) (see all 99)
    tumors 73.6 1071 17912438 (8), 10200702 (8), 8579108 (7), 11839564 (7) (see all 99)
    carcinoma 64.7 229 8567994 (5), 12534600 (4), 9826464 (4), 10547541 (3) (see all 99)
    cancer 61.5 294 11832714 (6), 11313172 (4), 9090502 (3), 7518345 (3) (see all 99)
    primary tumor 57.2 38 14666731 (3), 8682582 (2), 17006832 (2), 12854146 (2) (see all 26)
    colon carcinoma 54.2 55 18234849 (4), 8678563 (4), 11431370 (3), 8858111 (3) (see all 29)
    colorectal carcinoma 53.2 64 12782013 (4), 7504563 (3), 9754757 (3), 11911305 (3) (see all 33)
    adenocarcinoma 52.7 98 7537174 (5), 8599448 (4), 15717748 (4), 8608952 (3) (see all 61)
    aggressiveness 52.1 31 7576964 (3), 10846530 (3), 10355528 (2), 11213839 (1) (see all 20)
    carcinoma squamous cell 50.2 72 17679465 (4), 19900133 (3), 9725567 (3), 8599448 (2) (see all 45)

    Genetic Association Database (GAD): CD44
    Human Genome Epidemiology (HuGE) Navigator: CD44 (24 documents)

    Export disorders for CD44 gene to outside databases

    Publications
    for CD44 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD44 gene, integrated from 9 sources (see all 2115):
    (articles sorted by number of sources associating them with CD44)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase. (PubMed id 8352881)1, 2, 9 Tanabe K.K.... Saya H. (1993)
    2. Expression of CD44 is repressed in neuroblastoma cells. (PubMed id 1922057)1, 2, 9 Shtivelman E. and Bishop J.M. (1991)
    3. Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44. (PubMed id 10933060)1, 2, 9 Chiu R.K....Dougherty G.J. (1999)
    4. Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325. (PubMed id 9580567)1, 2, 9 Peck D. and Isacke C.M. (1998)
    5. CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. (PubMed id 1717145)1, 2, 9 Hofmann M....Guenthert U. (1991)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR. (PubMed id 17085435)1, 2 Takeda M.... Shimada I. (2006)
    8. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    9. Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. (PubMed id 14992719)1, 2 Teriete P.... Jackson D.G. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for CD44 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CD44 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 960 HGNC: 1681 AceView: CD44 Ensembl:ENSG00000026508 euGenes: HUgn960
    ECgene: CD44 Kegg: 960 H-InvDB: CD44

    Other Databases showing CD44 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CD44 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD44 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD44 Genetics and Cytogenetics in Oncology and Haematology
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=indian
    Wikipedia http://en.wikipedia.org/wiki/CD44

    Intellectual Property
    for CD44 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CD44 gene:
    Search GeneIP for patents involving CD44

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CD44 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of CD44
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     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
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