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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BRD4 Gene

protein-coding GIFtS: 59
GCID: GC19M015348

bromodomain containing 4

(Previous name: bromodomain-containing 4 )

Explore 4 diseases affiliated with
BRD4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Bromodomain Containing 4¹ ²		Bromodomain-Containing 4¹ ²
HUNK1¹ ² ³ ⁵		Bromodomain-Containing Protein 4²
CAP¹ ² ⁵		Chromosome-Associated Protein²
HUNKI¹ ²		Protein HUNK1³
MCAP¹ ²

External Ids:	HGNC: 13575¹	Entrez Gene: 23476²	Ensembl: ENSG00000141867⁷	OMIM: 608749⁵	UniProtKB: O60885³

Export aliases for BRD4 gene to outside databases

Previous GC identifers: GC19M015727 GC19M015193 GC19M015209 GC19M014916

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BRD4:

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during

mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains,

a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the

chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young

people. Two alternatively spliced transcript variants have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BRD4_HUMAN, O60885

Function: Plays a role in a process governing chromosomal dynamics during mitosis (By similarity)

Gene Wiki entry for BRD4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BRD4 gene promoter:
RFX1 NF-1 AP-1 p53 FOXO3 FOXO3a FOXO3b
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BRD4 promoter sequence

Search SABiosciences Chromatin IP Primers for BRD4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRD4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1 Ensembl cytogenetic band: 19p13.12 HGNC chromosome: 19

BRD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRD4 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M015348: view genomic region (about GC identifiers)

Start:	15,348,301 bp from pter	End:	15,443,356 bp from pter
Size:	95,056 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BRD4_HUMAN, O60885 (See protein sequence)

Recommended Name: Bromodomain-containing protein 4

Size: 1362 amino acids; 152219 Da

Subunit: Associated with chromosomes during mitosis (By similarity). Interacts with bovine papillomavirus type 1

regulatory protein E2

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=AAC27978.1; Type=Erroneous initiation;

6/30 PDB 3D structures from and Proteopedia for BRD4 (see all 30):

2I8N (3D)

2LSP (3D)

2NNU (3D)

2OSS (3D)

2OUO (3D)

2YEL (3D)

Secondary accessions: O60433 Q86YS8 Q96PD3

Alternative splicing: 2 isoforms: O60885-1 O60885-2

Explore the universe of human proteins at neXtProt for BRD4: NX_O60885

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60885

BRD4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_055114.1 NP_490597.1

ENSEMBL proteins:

ENSP00000263377 ENSP00000360901 ENSP00000353112

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for BRD4

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000790	nuclear chromatin	IEA	--
GO:0000794	condensed nuclear chromosome	IDA	10938129
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

BRD4 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for BRD4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BRD4 for domains About GeneDecksing

2 InterPro domains/families:

IPR018359 Bromodomain_CS

IPR001487 Bromodomain

Graphical View of Domain Structure for InterPro Entry O60885

ProtoNet protein and cluster: O60885

1 Blocks protein family: IPB001487 Bromodomain signature

UniProtKB/Swiss-Prot: BRD4_HUMAN, O60885

Similarity: Contains 2 bromo domains

Similarity: Contains 1 NET domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BRD4_HUMAN, O60885

Function: Plays a role in a process governing chromosomal dynamics during mitosis (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): BRD4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BRD4
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate BRD4 (see all 24):
		hsa-miR-623 hsa-miR-3910 hsa-miR-3938 hsa-miR-520d-5p hsa-miR-200a hsa-miR-1285 hsa-miR-507 hsa-miR-141

		SwitchGear 3'UTR luciferase reporter plasmid: BRD4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

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		Search LifeMap BioReagents cell lines for BRD4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD4

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	17474147

BRD4 for ontologies About GeneDecksing

8 GenomeRNAi human phenotypes for BRD4:

Decreased focal adhesion (FA)	Decreased substrate adherent c	Decreased viability of wild-ty	Increased HPV18 LCR reporter a
Increased cell death HMECs cel	Increased cilium length after	Synthetic lethal with c-Myc af	Upregulation of Wnt/beta-caten

Animal Models:
10 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Brd4):

craniofacial	embryogenesis	endocrine/exocrine gland	growth/size	integument
liver/biliary system	mortality/aging	reproductive system	skeleton	vision/eye

BRD4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for BRD4

Chromatin Regulation / Acetylation

BRD4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BRD4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/611 Interacting proteins for BRD4 (O60885^{1, 2, 3} ENSP00000263377⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 611)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=3 STRING: ENSP00000352980
HIST2H4A	P62805³, ENSP00000358162⁴	I2D: score=3 STRING: ENSP00000358162
HIST4H4	P62805³, ENSP00000350767⁴	I2D: score=3 STRING: ENSP00000350767
HIST1H4B	P62805³	I2D: score=3
HIST1H4C	P62805³	I2D: score=3

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000114	regulation of transcription involved in G1 phase of mitotic cell cycle	IMP	18039861
GO:0001833	inner cell mass cell proliferation	IEA	--
GO:0006468	protein phosphorylation	IEA	--
GO:0007059	chromosome segregation	IEA	--
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	IMP	10938129

BRD4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for BRD4 available from Tocris Bioscience About this table

Compound	Action	CAS #
PFI 1	BET bromodomain inhibitor	--

Search CenterWatch for drugs/clinical trials and news about BRD4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BRD4 gene (2 alternative transcripts):

NM_014299.2 NM_058243.2

Unigene Cluster for BRD4:

Bromodomain containing 4

Hs.187763 [show with all ESTs]

Unigene Representative Sequence: AF386649

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000263377(uc002nar.3) ENST00000371835(uc002nas.3) ENST00000360016(uc002nat.3 uc002nau.4)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): BRD4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BRD4
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate BRD4 (see all 24):
		hsa-miR-623 hsa-miR-3910 hsa-miR-3938 hsa-miR-520d-5p hsa-miR-200a hsa-miR-1285 hsa-miR-507 hsa-miR-141

		SwitchGear 3'UTR luciferase reporter plasmid: BRD4 3' UTR sequence

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BRD4 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BRD4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRD4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRD4

Additional cDNA sequence:

AF252390.1 AF386649.1 AK307664.1 BC000156.1 BC008354.1 BC030158.2 BC035266.1 BC038988.1

BC047888.1 BC067129.1 BC091649.1 Y12059.1

24/34 DOTS entries (see all 34):

DT.98084068 DT.439946 DT.452411 DT.101972749 DT.121496792 DT.95334361 DT.121496740 DT.95263031

DT.101969817 DT.121496804 DT.40108742 DT.97773958 DT.121496826 DT.100821651 DT.121496793 DT.95364305

DT.91975962 DT.121496932 DT.91992517 DT.92440035 DT.92440045 DT.95262997 DT.99972180 DT.100821647

24/502 AceView cDNA sequences (see all 502):

AI128514 CA446955 AI082147 BC035266 CA868546 CA868477 BQ645818 BU173686

AI125710 BQ674079 AI383992 BF513333 BF904819 AA384385 F31963 BE676412

AI278188 AA336067 BG287007 CF138206 BQ650970 BE294807 BQ014763 T51949

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for BRD4 (see all 13) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17a	·	17b	^	18	^	19	^	20	^	21	^	22	^	23	^	24a	·
SP1:																					-
SP2:
SP3:
SP4:
SP5:																																					-

ExUns:	24b	^	25	^	26	^	27	^	28	^	29	^	30
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for BRD4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BRD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCGCAAGC

About this image

BRD4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Early Gonad

Testis Somatic Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BRD4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BRD4

SOURCE GeneReport for Unigene cluster: Hs.187763

UniProtKB/Swiss-Prot: BRD4_HUMAN, O60885

Tissue specificity: Ubiquitously expressed

SABiosciences Expression via Pathway-Focused PCR Array including BRD4:

Epigenetic Chromatin Remodeling Factors in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRD4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for BRD4 gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Brd4^{1 , 5}	bromodomain containing 4^{1, 5}	88.89(n)¹ 95.74(a)¹		17 (17.39 cM)⁵ 57261¹ NM_020508.3¹ NP_065254.3¹ 32196274⁵
chicken (Gallus gallus)	Aves	LOC100859056¹	bromodomain-containing protein 4-like	78.56(n) 83.88(a)		100859056 XM_003643843.1 XP_003643891.1
lizard (Anolis carolinensis)	Reptilia	BRD4⁶	--	78(a)	1 ↔ 1	2(103323245-103369334)
zebrafish (Danio rerio)	Actinopterygii	brd4¹	bromodomain containing 4	62.7(n) 63.11(a)		570531 NM_001111281.1 NP_001104751.1
fruit fly (Drosophila melanogaster)	Insecta	fs(1)h³	regulation of transcription from Pol II promoter more	53(a)		--
worm (Caenorhabditis elegans)	Secernentea	bet-1⁶ bet-2⁶	Protein BET-2, isoform a	14(a) 10(a)	possible ortholog possible ortholog	I(4526379-4534801) X(10569057-10575659)
thale cress (Arabidopsis thaliana)	eudicotyledons	NPX1⁶ GTE3⁶ (see all 12)	bromodomain-containing protein GTE3 (see all 12)	9(a) 21(a) (see all 12)	possible ortholog many ↔ many (see all 12)	5(25374413-25379297) 1(27504112-27506112)
rice (Oryza sativa)	Liliopsida	-- -- (see all 11)	bromodomain domain containing protein, expressed (see all 11)	6(a) 28(a) (see all 11)	possible ortholog possible ortholog (see all 11)	8(1566556-1572065) 1(26172141-26176186)

ENSEMBL Gene Tree for BRD4 (if available)
TreeFam Gene Tree for BRD4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BRD4 gene

BRDT² CREBBP² BRD2² EP300² BRD3²

5 SIMAP similar genes for BRD4 using alignment to 9 protein entries: BRD4_HUMAN (see all proteins):

BRDT BRD3 DKFZp686N0336 DKFZp313H139 BRD2

BRD4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3179015^1,2	C,F	--	15347829(-)	`TTTTTA/TAATTT`	1	--	ds500¹		3		NA	6
rs186590936^1,2		--	15347988(+)	`AAAACA/CAAAAC`	1	--	ds500¹		0	--	--	--	--
rs147277784^1,2		--	15348217(+)	`TTTCAC/TACCAG`	1	--	ds500¹		0	--	--	--	--
rs116952107^1,2	C,	--	15348322(+)	`GCAGCC/TGCTGC`	1	--	ut3¹		1		NA	120
rs190600735^1,2	C,	--	15348525(+)	`ACCCAC/GGCAGG`	1	--	ut3¹		0	--	--	--	--
rs2286019^1,2	C,H	--	15348902(+)	`ATGTGG/AGGATG`	1	--	ut3¹ ese³		2		NS NA	102
rs113991798^1,2	C	--	15348926(+)	`CAGCCG/AGCACT`	1	--	ut3¹		1		CSA	2
rs183154747^1,2	C,	--	15348936(+)	`TTGCTC/TGTAAC`	1	--	ut3¹		0	--	--	--	--
rs138078796^1,2	C,	--	15349056(+)	`GCCCCA/GGGCAT`	1	--	ut3¹		0	--	--	--	--
rs187083313^1,2		--	15349125(+)	`CCGCCC/TCTAAC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BRD4 (15348301 - 15443356 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BRD4
1 CNV: 47932

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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BRD4 for disorders About GeneDecksing

OMIM gene information: 608749 OMIM disorders: --

UniProtKB/Swiss-Prot: BRD4_HUMAN, O60885

Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in

midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein

4 diseases for BRD4: About MalaCards

carcinoma kaposi's sarcoma sarcoma immunodeficiency

Export disorders for BRD4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BRD4 gene, integrated from 9 sources (see all 82):
(articles sorted by number of sources associating them with BRD4)

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A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition. (PubMed id 10938129)^{1, 3, 9} Dey A....Ozato K. (2000)
BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. (PubMed id 12543779)^{1, 2, 9} French C.A....Fletcher J.A. (2003)
BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). (PubMed id 11733348)^{1, 2, 9} French C.A.... Fletcher J.A. (2001)
ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance. (PubMed id 17189189)^{1, 2} Parish J.L....Androphy E.J. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
Abrogation of the Brd4-positive transcription elongat ion factor B complex by papillomavirus E2 protein contributes to viral oncogene repression. (PubMed id 19846528)^{1, 9} Yan J....You J. (2010)
Chromatin adaptor Brd4 modulates E2 transcription activity and protein stability. (PubMed id 19038968)^{1, 9} Lee A.Y. and Chiang C.M. (2009)
Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization. (PubMed id 15456879)^{1, 9} Farina A....Ozato K. (2004)
Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4. (PubMed id 19211738)^{1, 9} Gagnon D....Archambault J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23476	HGNC: 13575	AceView: BRD4	Ensembl:ENSG00000141867	euGenes: HUgn23476
ECgene: BRD4	H-InvDB: BRD4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BRD4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BRD4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for BRD4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BRD4 gene:
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GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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