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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BMP15 Gene

protein-coding   GIFtS: 56
GCID: GC0XP050670

bone morphogenetic protein 15
 Explore 14 diseases affiliated with
BMP15 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BMP15    

Aliases
for BMP15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Bone Morphogenetic Protein 151 2     GDF-9B2 3
GDF9B1 2 3 5     ODG22 5
Growth/Differentiation Factor 9B2 3     POF42 5
BMP-152 3     

External Ids:    HGNC: 10681   Entrez Gene: 92102   Ensembl: ENSG000001303857   OMIM: 3002475   UniProtKB: O959723   

Export aliases for BMP15 gene to outside databases

Previous GC identifers: GC0XP049198 GC0XP048656 GC0XP049338 GC0XP049570 GC0XP050486 GC0XP048097


Summaries
for BMP15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BMP15:
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming
growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and
differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular
development as a homodimer or by forming heterodimers with a related protein, Gdf9. Defects in this gene are the cause
of ovarian dysgenesis 2.(provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: BMP15_HUMAN, O95972
Function: May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates
folliculogenesis and granulosa cell (GC) growth

Gene Wiki entry for BMP15 (Bone morphogenetic protein 15)


Genomic Views
for BMP15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011638.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BMP15 gene promoter:
         RP58   AML1a   MIF-1   STAT5A   Nkx2-5   NF-E2 p45   POU2F1   POU2F1a   Chx10   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BMP15 promoter sequence
   Search SABiosciences Chromatin IP Primers for BMP15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BMP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.2

BMP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BMP15 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP050670:  view genomic region     (about GC identifiers)

Start:
 50,653,735 bp from pter      End:
 50,659,641 bp from pter
Size:
 5,907 bases      Orientation:
 plus strand

Proteins
for BMP15 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BMP15_HUMAN, O95972 (See protein sequence)
Recommended Name: Bone morphogenetic protein 15 precursor  
Size: 392 amino acids; 45055 Da
Subunit: Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked
Subcellular location: Secreted
Miscellaneous: The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa)
Miscellaneous: Ovarian physiology and fertility are controlled by endocrine and paracrine signals. These act in a
species-dependent manner and determine the ovulation quota in different mammalian species. While humans, and mammals
such as the cow or red deer, normally ovulate only one egg per cycle, other mammals such as mouse and pig can ovulate
in excess of ten per cycle. The mechanisms that regulate the species-specific differences in the number of follicles
that go onto ovulate during each reproductive cycle are poorly understood. According to PubMed:21970812, mRNA
expression levels of GDF9 and BMP15 are tightly co-regulated within each species and influence species-specific
ovulation-rates
Secondary accessions: Q17RM6 Q5JST1 Q9UMS1

Explore the universe of human proteins at neXtProt for BMP15: NX_O95972

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95972

    • BMP15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005439.2  
    ENSEMBL proteins: 
     ENSP00000252677  

    Human Recombinant Protein Products: 
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    Uscn Proteins for BMP15

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--


    BMP15 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for BMP15

    Protein Domains /
    Families
    for BMP15 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BMP15 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002405 Inhibin_asu
     IPR015615 TGF-beta-rel
     IPR015923 BMP-15
     IPR001839 TGF-b_C
     IPR017948 TGFb_CS

    Graphical View of Domain Structure for InterPro Entry O95972

    ProtoNet protein and cluster: O95972

    2 Blocks protein families:
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002405 Inhibin alpha chain signature


    UniProtKB/Swiss-Prot: BMP15_HUMAN, O95972
    Similarity: Belongs to the TGF-beta family


    Function
    for BMP15 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BMP15_HUMAN, O95972
    Function: May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates
    folliculogenesis and granulosa cell (GC) growth

         Genatlas biochemistry entry for BMP15:
    bone morphogenetic protein 15,expressed in oocytes,co-localized with GDF9,and likely involved in follicular development

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: BMP15
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for BMP15

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0008083growth factor activity IEA--


    BMP15 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Bmp15tm1Zuk for BMP15
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bmp15):
     endocrine/exocrine gland  reproductive system 

    BMP15 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BMP15 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/11 pathways (see all 11)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    3Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    4Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    5PAK Pathway
    		PAK Pathway1.00
    		Antioxidant Action of Vitamin-C0.56

    5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BMP15 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BMP15

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for BMP15 (O959723 ENSP000002526774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GDF9O603833, ENSP000002968754I2D: score=1 STRING: ENSP00000296875
    BMPR1BO002383, ENSP000002645684I2D: score=1 STRING: ENSP00000264568
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0007292female gamete generation TAS9849956
    GO:0060016granulosa cell development IEA--


    BMP15 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BMP15 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BMP15 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BMP15
    1 Novoseek chemical compound relationship for BMP15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 0 6 12419820 (2), 17347167 (1)

    Search CenterWatch for drugs/clinical trials and news about BMP15 

    Transcripts
    for BMP15 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BMP15 gene: 
    NM_005448.2  

    Unigene Cluster for BMP15:

    Bone morphogenetic protein 15
    Hs.532692
    Unigene Representative Sequence: NM_005448
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252677(uc011mnw.2)

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: BMP15
    OriGene siRNA: BMP15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BMP15
    Clone
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    GenScript: all cDNA clones in your preferred vector: BMP15 (NM_005448)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BMP15

    Additional cDNA sequence: 

    BC069155.1 BC117264.1 BC117266.1 

    1 DOTS entry:

    DT.91935579 

    2 AceView cDNA sequences:

    NM_005448 BC069155 

    GeneLoc Exon Structure


    Expression
    for BMP15 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BMP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGATGACAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BMP15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    OvaryPrimordial FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    LiverHepatic MesenchymeMesothelial CellsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Secondary follicles (Primary Cell)Ovary, Reproductive System
    Mature follicles (In-vitro growth and ...)

    See BMP15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BMP15

    SOURCE GeneReport for Unigene cluster: Hs.532692
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    In Situ
    Assay Products:     
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    Orthologs
    for BMP15 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for BMP15 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BMP151 bone morphogenetic protein 15 54.07(n)
    46.95(a)    		   428697  NM_001006589.2  NP_001006589.2 
    lizard
    (Anolis carolinensis)    		 Reptilia BMP156
    		 --
    		 36(a)
    		 1 ↔ 1
    		 GL344585.1(17744-20559)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.185942 Xenopus laevis transcribed sequence with weak similarity more 75.33(n)    AW636224.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi35a052 Transcribed sequence with weak similarity to protein more 73.69(n)    57065642 


    ENSEMBL Gene Tree for BMP15 (if available)
    TreeFam Gene Tree for BMP15 (if available) 

    Paralogs
    for BMP15 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BMP15 gene
    NODAL2  GDF92  GDF152  

    BMP15 for paralogs           About GeneDecksing



    Genomic Variants
    for BMP15 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/130 NCBI SNPs in BMP15 are shown (see all 130)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1048947631,2
    		C,F,pathogenic50653985(+) CACTGC/TGGTAC 2 R W mis11Minor allele frequency- T:0.00NA 3478
    rs734880221,2
    		C,--50651760(+) CAACCG/TTAACA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1875677401,2
    		--50652009(+) TGTTTC/TCAGTT 1 -- us2k10--------
    rs1925616661,2
    		--50652016(+) AGTTGC/TGTTTT 1 -- us2k10--------
    rs1403532291,2
    		--50652017(+) GTTGCA/GTTTTT 1 -- us2k10--------
    rs1454154941,2
    		--50652038(+) GTACAC/TCTTTT 1 -- us2k10--------
    rs1381387071,2
    		--50652429(+) TAAAAC/TGTGTT 1 -- us2k10--------
    rs1495248271,2
    		--50652721(+) CAGATC/GCCCAT 1 -- us2k10--------
    rs66143691,2
    		C,H--50652839(+) CTGGGC/ATAGGT 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1441424641,2
    		--50652860(+) AGATTA/GCTCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BMP15 (50653735 - 50659641 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BMP15: --
    Human Gene Mutation Database (HGMD): BMP15

    Locus Specific Mutation Databases (LSDB): BMP15

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BMP15
    DNA2.0 Custom Variant and Variant Library Synthesis for BMP15

    Disorders / Diseases
    for BMP15 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BMP15 for disorders           About GeneDecksing

    OMIM gene information: 300247   
    OMIM disorders: 300510  
    UniProtKB/Swiss-Prot: BMP15_HUMAN, O95972
  • Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2) [MIM:300510]; also known as X-linked
    • hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian
    dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea
  • Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4) [MIM:300510]. An ovarian disorder
    • defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or
    amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol

    14 diseases for BMP15:    About MalaCards
    ovarian dysgenesis    ovarian dysgenesis 2    premature ovarian failure 4    premature ovarian failure
    polycystic ovary syndrome    gonadal dysgenesis    freemartinism    turner syndrome
    ovarian hyperstimulation syndrome    anovulation    amenorrhea    infertility
    twinning    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for BMP15:
    Premature ovarian failure     Infertility     Amenorrhea     Polycystic ovary syndrome

    7 Novoseek disease relationships for BMP15 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian failure premature 87.2 15 16645022 (2), 17027369 (2), 17464588 (2), 20364024 (2) (see all 8)
    ovarian dysgenesis 73.9 2 15836954 (1)
    infertility female 62.6 2 16818886 (1)
    infertility 47.3 7 10888873 (2), 15836954 (1), 18308851 (1)
    polycystic ovary syndrome 32.7 4 19376510 (2), 11056243 (1)
    turners syndrome 32.5 1 12478993 (1)
    tumors 2.58 1 16818886 (1)

    Human Genome Epidemiology (HuGE) Navigator: BMP15 (13 documents)

    Export disorders for BMP15 gene to outside databases

    Publications
    for BMP15 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BMP15 gene, integrated from 9 sources (see all 98):
    (articles sorted by number of sources associating them with BMP15)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. (PubMed id 9849956)1, 2, 3, 9 Dube J.L.... Matzuk M.M. (1998)
    2. Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene. (PubMed id 15136966)1, 2, 9 Di Pasquale E.... Persani L. (2004)
    3. Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis. (PubMed id 10443672)1, 2, 9 Aaltonen J.... Ritvos O. (1999)
    4. BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein. (PubMed id 19263482)1, 2, 9 Rossetti R....Persani L. (2009)
    5. Missense mutations in the BMP15 gene are associated with ovarian failure. (PubMed id 16508750)1, 2, 9 Dixit H.... Singh L. (2006)
    6. Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure. (PubMed id 16645022)1, 2, 9 Laissue P.... Veitia R.A. (2006)
    7. Characterization of the post-translational modification of recombinant human BMP-15 mature protein. (PubMed id 18227435)1, 2, 9 Saito S.... Shimasaki S. (2008)
    8. Analyses of growth differentiation factor 9 (GDF9) an d bone morphogenetic protein 15 (BMP15) mutation in Chinese women with prematur e ovarian failure. (PubMed id 19438907)1, 2, 9 Wang B....Ma X. (2010)
    9. Identification of new variants of human BMP15 gene in a large cohort of women with premature ovarian failure. (PubMed id 16464940)1, 2 Di Pasquale E.... Persani L. (2006)
    10. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)

    External Searches for BMP15 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing BMP15 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9210 HGNC: 1068 AceView: BMP15 Ensembl:ENSG00000130385 euGenes: HUgn9210
    ECgene: BMP15 H-InvDB: BMP15

    Other Databases showing BMP15 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BMP15 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BMP15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BMP15 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for BMP15 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BMP15 gene:
    Search GeneIP for patents involving BMP15

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