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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BCL2L11 Gene

protein-coding GIFtS: 67
GCID: GC02P111876

BCL2-like 11 (apoptosis facilitator)

Explore 60 diseases affiliated with
BCL2L11 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BCL2-Like 11 (Apoptosis Facilitator)¹ ²		Bcl-2 Interacting Mediator Of Cell Death²
BIM¹ ² ³ ⁵		Bcl-2 Interacting Protein Bim²
BOD¹ ²		Bcl-2-Like Protein 11²
BimEL¹		Bcl-2-Related Ovarian Death Agonist²
BimL¹		Bcl2-L-11³
BimS¹		Bcl2-L-11³
BAM²		Bcl2-Interacting Mediator Of Cell Death³

External Ids:	HGNC: 994¹	Entrez Gene: 10018²	Ensembl: ENSG00000153094⁷	OMIM: 603827⁵	UniProtKB: O43521³

Export aliases for BCL2L11 gene to outside databases

Previous GC identifers: GC02P109111 GC02P109802 GC02P111785 GC02P111976 GC02P111597 GC02P104757

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BCL2L11:

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers

and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein

encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the

BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression

of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1,

which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart

suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several

alternatively spliced transcript variants of this gene have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: B2L11_HUMAN, O43521

Function: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform

Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform

BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated

pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis

summary for BCL2L11:

Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein

family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as

Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. The pro-apoptotic group of Bcl-2

proteins can be further sub-divided into the structurally diverse 'BH3' only proteins (e.g. Bid, Noxa, Puma

and Bad) and the multidomain proteins that share BH1 to 3 (e.g. Bax and Bak). Most Bcl-2 family members

contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial

and other intracellular membranes.

Gene Wiki entry for BCL2L11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022135.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BCL2L11 gene promoter:
AML1a Pax-5 C/EBPalpha CREB CHOP-10 deltaCREB Chx10 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): BCL2L11 promoter sequence

Search SABiosciences Chromatin IP Primers for BCL2L11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BCL2L11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13

BCL2L11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BCL2L11 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P111876: view genomic region (about GC identifiers)

Start:	111,876,955 bp from pter	End:	111,926,022 bp from pter
Size:	49,068 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: B2L11_HUMAN, O43521 (See protein sequence)

Recommended Name: Bcl-2-like protein 11

Size: 198 amino acids; 22171 Da

Subunit: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform

Bcl-X(L), BCL2A1/BFL-1, BHRF1, and BCLW. Isoform BimS and isoform Bim-alpha3 interact with BAX; this interaction

induces the conformationally active form of BAX. Does not heterodimerize with proapoptotic proteins such as BAD, BOK

or BAK (By similarity). Interacts with DYNLL1 and YWHAZ (By similarity). When phosphorylated, interacts with TRIM2;

this interaction is associated with ubiquitination and degradation (By similarity)

Subcellular location: Endomembrane system; Peripheral membrane protein (By similarity). Note=Associated with

intracytoplasmic membranes (By similarity)

Subcellular location: Isoform BimEL: Mitochondrion. Note=Translocates from microtubules to motochondria on loss of cell

adherence

Subcellular location: Isoform BimL: Mitochondrion

Subcellular location: Isoform BimS: Mitochondrion

Subcellular location: Isoform Bim-alpha1: Mitochondrion

6/14 PDB 3D structures from and Proteopedia for BCL2L11 (see all 14):

2K7W (3D)

2NL9 (3D)

2V6Q (3D)

2VM6 (3D)

2WH6 (3D)

2YQ6 (3D)

Secondary accessions: A8K2W2 O43522 Q0MSE7 Q0MSE8 Q0MSE9 Q53R28 Q6JTU6 Q6T851 Q6TE14 Q6TE15 Q6TE16

Q6V402 Q8WYL6 Q8WYL7 Q8WYL8 Q8WYL9 Q8WYM0 Q8WYM1

Alternative splicing: 20 isoforms: O43521-1 O43521-2 O43521-3 O43521-4 O43521-5 O43521-6 O43521-7 O43521-8

O43521-9 O43521-10 O43521-11 O43521-12 O43521-13 O43521-14 O43521-15 O43521-16

O43521-17 O43521-18 O43521-19 O43521-20

Explore the universe of human proteins at neXtProt for BCL2L11: NX_O43521

Post-translational modifications:

Phosphorylation at Ser-69 by MAPK1/MAPK3 induces interaction with TRIM2, followed by polyubiquitination¹

Ubiquitinated by TRIM2 following phosphorylation by MAPK1/MAPK3, leading to degradation by the proteasome (By

similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43521

BCL2L11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (18 alternative transcripts):

NP_001191035.1 NP_001191036.1 NP_001191037.1 NP_001191038.1 NP_001191039.1 NP_001191040.1 NP_001191041.1 NP_001191042.1

NP_006529.1 NP_619527.1 NP_619528.1 NP_619529.1 NP_619530.1 NP_619531.1 NP_619532.1 NP_619533.1

NP_996885.1 NP_996886.1

ENSEMBL proteins:

ENSP00000411870 ENSP00000309226 ENSP00000376943 ENSP00000376941 ENSP00000401662

ENSP00000384641 ENSP00000393781 ENSP00000403727 ENSP00000412892 ENSP00000391292

ENSP00000354879 ENSP00000394640 ENSP00000411137 ENSP00000389225 ENSP00000350398

ENSP00000376942 ENSP00000338374

Reactome Protein details: O43521
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for BCL2L11
	Uscn Proteins for BCL2L11

Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000300	peripheral to membrane of membrane fraction	--	--
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	--	--
GO:0005741	mitochondrial outer membrane	TAS	--
GO:0005829	cytosol	TAS	--

BCL2L11 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BCL2L11 for domains About GeneDecksing

3 InterPro domains/families:

IPR017288 Bcl-2-like_11

IPR015040 Bcl-x_interacting

IPR014771 Apoptosis_Bim_N

Graphical View of Domain Structure for InterPro Entry O43521

ProtoNet protein and cluster: O43521

1 Blocks protein family: IPB009616 Bim

UniProtKB/Swiss-Prot: B2L11_HUMAN, O43521

Domain: The BH3 motif is required for Bcl-2 binding and cytotoxicity

Similarity: Belongs to the Bcl-2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: B2L11_HUMAN, O43521

Function: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform

Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform

BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated

pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis

Induction: By ER stress in a DDIT3/CHOP-dependent manner

miRNA Products:		miRTarBase miRNAs that target BCL2L11: hsa-mir-17 (MIRT001206), hsa-mir-32 (MIRT003739), hsa-mir-195 (MIRT000785), hsa-mir-181a (MIRT005767), hsa-mir-19a (MIRT004452), hsa-mir-25 (MIRT003413), hsa-mir-19b (MIRT004523)

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BCL2L11

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	18677096
GO:0008017	microtubule binding	IEA	--
GO:0046982	protein heterodimerization activity	IEA	--

BCL2L11 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for BCL2L11:

G0/1 arrest

Increased G1 DNA content

Animal Models:
Mouse knock-outs for BCL2L11: Bcl2l11^tm4Rjd Bcl2l11^tm1Ast Bcl2l11^tm1Sjk Bcl2l11^tm1.1Ast
15/18 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Bcl2l11) (see all 18):

cardiovascular system	cellular	endocrine/exocrine gland	growth/size	hearing/vestibular/ear
hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail
mortality/aging	nervous system	no phenotypic analysis	normal	pigmentation

BCL2L11 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	1.00	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins	0.24
Activation of BH3-only proteins	0.30	Intrinsic Pathway for Apoptosis	0.23
Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins	0.24

Cell death signalling via NRAGE, NRIF and NADE

	Cell death signalling via NRAGE, NRIF and NADE	1.00			p75 NTR receptor-mediated signalling	0.73
	NRAGE signals death through JNK	0.74

Apoptosis Modulation and Signaling

Apoptosis Modulation and Signaling

1.00

Apoptosis

0.38

Apoptotic Pathways in Synovial Fibroblasts

Mitochondrial Apoptosis

0.73

Cellular Apoptosis Pathway

0.65

Development IGF-RI signaling

Signal transduction_AKT signaling

0.49

Signal transduction AKT signaling

0.49

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for BCL2L11

	Apoptosis and survival FAS signaling cascades
	Signal transduction AKT signaling
	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BCL2L11

	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer
	14-3-3 and Regulation of BAD Activity
	Cellular Apoptosis Pathway

1 Cell Signaling Technology (CST) Pathway for BCL2L11

Apoptosis and Autophagy

3 GeneGo (Thomson Reuters) Pathways for BCL2L11

	Apoptosis and survival FAS signaling cascades
	Signal transduction AKT signaling
	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins

5/9 BioSystems Pathways for BCL2L11 (see all 9)

	Apoptosis Modulation and Signaling
	ErbB signaling pathway
	Apoptosis
	DNA damage response (only ATM dependent)
	IL-3 Signaling Pathway

5/10 Reactome Pathways for BCL2L11 (see all 10)

	Activation of BH3-only proteins
	Cell death signalling via NRAGE, NRIF and NADE
	Activation of BIM and translocation to mitochondria
	NRAGE signals death through JNK
	p75 NTR receptor-mediated signalling

BCL2L11 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BCL2L11

5/36 Interacting proteins for BCL2L11 (O43521^{1, 2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAX	Q07812¹^,²^,³	EBI-1002160,EBI-516580 MINT-4980301 MINT-7034079 MINT-4980279 MINT-7034069 MINT-7034114 MINT-4980319 I2D: score=2
MCL1	Q07820¹^,²^,³	EBI-1002160,EBI-1003422 MINT-68751 MINT-4980348 MINT-4980279 MINT-4980319 MINT-7543162 I2D: score=12
BCL2	P10415¹^,²^,³	EBI-1002160,EBI-77694 MINT-6629252 MINT-4980319 I2D: score=12
BCL2L2	Q92843¹^,³	EBI-1002160,EBI-707714 I2D: score=5
BCL2L2-PABPN1	Q92843¹^,³	EBI-1002160,EBI-707714 I2D: score=5

About this table

Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0001776	leukocyte homeostasis	--	--
GO:0001782	B cell homeostasis	IEA	--
GO:0001783	B cell apoptotic process	IEA	--
GO:0001822	kidney development	IEA	--

BCL2L11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BCL2L11 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for BCL2L11 available from Tocris Bioscience About this table

Compound	Action	CAS #
BIM, Biotinylated	Bim peptide fragment	--

10/33 Novoseek chemical compound relationships for BCL2L11 gene (see all 33) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
noxa	88.3	54	18794091 (4), 16888645 (4), 17525724 (4), 17618288 (3) (see all 23)
bortezomib	70.6	12	15767553 (5), 16528474 (1), 17545623 (1), 15766661 (1)
suberoylanilide hydroxamic acid	66.6	8	18505786 (2), 17470784 (1), 19330811 (1), 17351739 (1)
sp 600125	59.1	1	17698840 (1)
mg 132	55	5	16230407 (2), 18064628 (1), 16431916 (1)
ly294002	50.6	7	18251703 (1), 12618753 (1), 18266951 (1), 15855272 (1) (see all 5)
gossypol	48.6	11	16258364 (2), 17156797 (1)
imatinib	48.5	34	15688014 (7), 16230407 (4), 15226421 (3), 20231287 (2) (see all 10)
depsipeptide	45.6	8	19308286 (4), 15069698 (1)
etoposide	35.8	2	16778834 (2)

Search CenterWatch for drugs/clinical trials and news about BCL2L11 / B2L11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BCL2L11 gene (18 alternative transcripts):

NM_001204106.1 NM_001204107.1 NM_001204108.1 NM_001204109.1 NM_001204110.1 NM_001204111.1 NM_001204112.1 NM_001204113.1

NM_006538.4 NM_138621.4 NM_138622.3 NM_138623.3 NM_138624.3 NM_138625.3 NM_138626.3 NM_138627.3

NM_207002.3 NM_207003.2

Unigene Clusters for BCL2L11:

BCL2-like 11 (apoptosis facilitator)

Hs.469658 [show with all ESTs], Hs.737004 [show with all ESTs]

Unigene Representative Sequences: NM_001204108, BI906766

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000432179 ENST00000308659 ENST00000393256(uc002thb.2 uc002tgx.2 uc021vmp.1 uc010fkd.2 uc002tgz.2 uc002thd.2 uc002tha.2 uc010fke.2 uc021vmq.1 uc002thc.2 uc021vmr.1 uc002tgw.2 uc021vms.1 uc002tgu.1 uc002tgy.2 uc002tgv.1)

ENST00000393252 ENST00000433098 ENST00000405953 ENST00000415458 ENST00000436733

ENST00000437029 ENST00000452231 ENST00000361493 ENST00000431217 ENST00000439718

ENST00000438054(uc021vmo.1) ENST00000357757 ENST00000393253 ENST00000337565(uc002tgt.1)

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Additional cDNA sequence:

AB071198.1 AB071200.1

11 DOTS entries:

DT.100662647 DT.100755121 DT.75123969 DT.447772 DT.95270536 DT.121016827 DT.100022202 DT.101982651

DT.121016869 DT.121016872 DT.91827574

24/185 AceView cDNA sequences (see all 185):

AA019073 BE501235 AA776827 BU618218 AW136146 NM_138627 AI590070 NM_138622

H85882 NM_138625 AB071198 AA857637 AA016186 AA748859 NM_138624 AA346887

AI424081 AA687226 BQ446484 AA861490 NM_207002 AI151517 CA413578 AI261753

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2L11 (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b
SP1:					-		-								-
SP2:					-		-						-
SP3:													-		-
SP4:					-		-
SP5:					-		-						-		-

ECgene alternative splicing isoforms for BCL2L11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BCL2L11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGTGGTTC

About this image

BCL2L11 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Cartilage-like cells (Differentiation of s...)

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BCL2L11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BCL2L11

SOURCE GeneReport for Unigene clusters: Hs.469658 Hs.737004

UniProtKB/Swiss-Prot: B2L11_HUMAN, O43521

Tissue specificity: Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously

expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and

colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including BCL2L11:

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Apoptosis in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for BCL2L11 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Bcl2l11^{1 , 5}	BCL2-like 11 (apoptosis facilitator)^{1, 5}	89.35(n)¹ 89.18(a)¹		2 (62.23 cM)⁵ 12125¹ NM_207680.2¹ NP_997563.1¹ 128126038⁵

ENSEMBL Gene Tree for BCL2L11 (if available)
TreeFam Gene Tree for BCL2L11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72836345^1,2	C,F,	--	104755694(+)	`TTTAGT/CGCCCC`	18	--	us2k¹		1		NA	120
rs72836346^1,2	C,F,	--	104755768(+)	`CGAGAG/CCGAGC`	18	--	us2k¹		1		NA	120
rs7577824^1,2	C,F,A,	--	104755918(+)	`GCTTCG/AGGCTC`	18	--	us2k¹		7		WA NA CSA EA	366
rs7593638^1,2	C,F,A,	--	104756096(+)	`AAATAA/CCTGGG`	18	--	us2k¹		6		WA NA CSA EA	364
rs13416333^1,2	C,	--	104757045(+)	`GGTGGC/TAGGAG`	18	--	us2k¹		1		WA	2
rs61016769^1,2	F,	--	104757144(+)	`GGGAGG/AAGAGC`	18	--	us2k¹		1		WA	118
rs62163309^1,2		--	104757254(+)	`CTCCCC/GAGGCT`	18	--	us2k¹		0	--	--	--	--
rs3929143^1,2		--	104757717(-)	`gcggcG/Agcggc`	18	--	ut5¹		1		NA	2
rs116907128^1,2	C,F,	--	104757851(+)	`CGCCTC/AGGCGC`	18	--	ut5¹		1		EA	120
rs72948325^1,2	C,	--	104758079(+)	`TGGATC/TGGGTT`	18	--	int¹		1		WA	2

HapMap Linkage Disequilibrium report for BCL2L11 (111876955 - 111926022 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BCL2L11
1 CNV: 3384
Human Gene Mutation Database (HGMD): BCL2L11

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BCL2L11 for disorders           About GeneDecksing

OMIM gene information: 603827    OMIM disorders: --

20/60 diseases for BCL2L11 (see all 60):    About MalaCards

interleukin-7 receptor alpha deficiency large granular lymphocyte leukemia temporal lobe epilepsy non-hodgkin lymphoma

infectious mononucleosis gastrointestinal stromal tumor burkitt's lymphoma b-cell lymphomas

glucocorticoid resistance lymphocytic leukemia hodgkin's lymphoma acute lymphoblastic leukemia

chronic lymphocytic leukemia malignant mesothelioma chronic myeloid leukemia lymphoblastic leukemia

neuronitis follicular lymphoma myeloid leukemia leptospirosis

2 diseases from the University of Copenhagen DISEASES database for BCL2L11:

Leukemia Lymphoma

10/18 Novoseek disease relationships for BCL2L11 gene (see all 18) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloma	42.5	16	15459900 (4), 19914305 (2), 17158029 (2), 17681275 (1) (see all 9)
tumors	41	38	15079075 (3), 19881544 (2), 18794091 (2), 15766661 (2) (see all 22)
cancer	39.8	7	19308286 (1), 20112357 (1), 19904742 (1), 16443928 (1) (see all 6)
melanoma	32.6	38	17637819 (6), 18715233 (5), 17051334 (2), 17652623 (2) (see all 8)
leukemia	23.8	9	19773546 (2), 17233818 (2), 19850739 (1), 14996839 (1) (see all 7)
burkitt lymphoma	22.8	4	16116183 (1), 19332026 (1), 18193085 (1)
lymphoma	20.6	7	16094360 (2), 17470784 (1), 15505424 (1), 17525724 (1) (see all 5)
breast cancer	19.3	9	14527951 (3), 17914587 (1), 16443928 (1), 19242112 (1) (see all 7)
prostate cancer	17.2	6	12019181 (2), 15767553 (1), 12629510 (1)
pancreatic cancer	15.5	1	16258364 (1)

Human Genome Epidemiology (HuGE) Navigator: BCL2L11 (10 documents)

Export disorders for BCL2L11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BCL2L11 gene, integrated from 9 sources (see all 491):
(articles sorted by number of sources associating them with BCL2L11)

Utopia: connect your pdf to the dynamic
world of online information

Bim: a novel member of the Bcl-2 family that promotes apoptosis. (PubMed id 9430630)^{1, 2, 3} O'Connor L.... Huang D.C.S. (1998)
Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis. (PubMed id 15147734)^{1, 2, 9} Chen J.Z.... Mao Y.M. (2004)
Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. (PubMed id 12019181)^{1, 2, 9} Liu J.-W.... Tang D.G. (2002)
Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family. (PubMed id 11734221)^{1, 2, 9} U M.... Yamada M. (2001)
Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. (PubMed id 21478148)^{1, 2} Thompson S.... Meller R. (2011)
Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim. (PubMed id 18812174)^{1, 2} Herman M.D....Nordlund P. (2008)
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. (PubMed id 17289999)^{1, 2} Willis S.N....Huang D.C. (2007)
BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors. (PubMed id 15486195)^{1, 2} Fukazawa H....Uehara Y. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. (PubMed id 11997495)^{1, 2} Marani M....Lemoine N.R. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10018	HGNC: 994	AceView: BCL2L11	Ensembl:ENSG00000153094	euGenes: HUgn10018
ECgene: BCL2L11	H-InvDB: BCL2L11

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for BCL2L11	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BCL2L11	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for BCL2L11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BCL2L11 gene:
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GeneCards and IP:
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BCL2L11 Gene

BCL2-like 11 (apoptosis facilitator)

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BCL2L11 Gene

BCL2-like 11 (apoptosis facilitator)

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