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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ATF7 Gene

protein-coding   GIFtS: 56
GCID: GC12M053905

activating transcription factor 7
 Explore 2 diseases affiliated with
ATF7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ATF7    

Aliases
for ATF7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Activating Transcription Factor 71 2 3
ATFA1 2 3
Transcription Factor ATF-A2 3
Cyclic AMP-Dependent Transcription Factor ATF-72
CAMP-Dependent Transcription Factor ATF-73

External Ids:    HGNC: 7921   Entrez Gene: 110162   Ensembl: ENSG000001706537   OMIM: 6063715   UniProtKB: P175443   

Export aliases for ATF7 gene to outside databases

Previous GC identifers: GC12M054022 GC12M053626 GC12M052196 GC12M050945


Summaries
for ATF7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ATF7_HUMAN, P17544
Function: Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus:
5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A
site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation
of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family
Function: Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter
Function: Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It
may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation

Gene Wiki entry for ATF7


Genomic Views
for ATF7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ATF7 gene promoter:
         TBP   MEF-2   CUTL1   AREB6   FOXO4   HOXA5   HSF2   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ATF7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ATF7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ATF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

ATF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ATF7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053905:  view genomic region     (about GC identifiers)

Start:
 53,901,640 bp from pter      End:
 54,020,199 bp from pter
Size:
 118,560 bases      Orientation:
 minus strand

Proteins
for ATF7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATF7_HUMAN, P17544 (See protein sequence)
Recommended Name: Cyclic AMP-dependent transcription factor ATF-7  
Size: 494 amino acids; 52967 Da
Subunit: Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN
family members. Interacts with JNK2; the interaction does not phosphorylate ATF7 but acts as a docking site for other
ATF-associated partners such as JUN family members. Interacts (via its transactivation domain) with TAF12 (isoforms
TAFII15 and TAFII20); the interaction potentiates the transactivation activity (isoform TAFII20 only) and is inhibited
by ATF7 sumoylation. Interacts with TAF4; the interaction inhibits the TAF12-dependent transactivation. Interacts with
adenovirus 2 E1A; the interaction enhances the ATF7-mediated viral transactivation activity which requires the
zinc-binding domains of both E1A and ATF7. Interacts with MAPK9; the interaction does not phosphorylate ATF7 but acts
as a docking site for ATF7-associated partners such as JUN
Subcellular location: Nucleus. Nucleus, nucleoplasm. Note=Mainly nucleoplasmic. Restricted distribution to the
perinuculear region. The sumoylated form locates to the nuclear periphery
Subcellular location: Isoform 5: Cytoplasm
Secondary accessions: A5D6Y4 B2RMP1 B4DQL4 Q13814 Q8IVR8 Q9UD83
Alternative splicing: 6 isoforms:  P17544-1   P17544-2   P17544-3   P17544-4   P17544-5   P17544-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ATF7: NX_P17544

Post-translational modifications:

  • On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter
    • phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity1
  • Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12.
    • RANBP2 appears to be the specific E3 ligase1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17544

    • ATF7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001123532.1  NP_001193611.1  NP_001193612.1  NP_006847.1  

    ENSEMBL proteins: 
     ENSP00000449938   ENSP00000399465   ENSP00000387406   ENSP00000465850   ENSP00000449817  
     ENSP00000468623   ENSP00000456858   ENSP00000465192   ENSP00000329212   ENSP00000404880  

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    Uscn Proteins for ATF7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8288576
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm IDA--
    GO:0034399nuclear periphery IDA17264123


    ATF7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ATF7

    Protein Domains /
    Families
    for ATF7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ATF7 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR004827 bZIP
     IPR015880 Znf_C2H2-like
     IPR016378 TF_cAMP-dep
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17544

    ProtoNet protein and cluster: P17544

    1 Blocks protein family: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: ATF7_HUMAN, P17544
    Similarity: Belongs to the bZIP family
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain
    Similarity: Contains 1 C2H2-type zinc finger


    Function
    for ATF7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ATF7_HUMAN, P17544
    Function: Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus:
    5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A
    site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation
    of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family
    Function: Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter
    Function: Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It
    may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation

    miRNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI15735663
    GO:0008134transcription factor binding IDA10376527
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--


    ATF7 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for ATF7:
     Decreased number of cells in m  Decreased viability  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         Mouse knock-outs for ATF7: Atf7tm1Sis Atf7tm1Nicj
         11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Atf7):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  liver/biliary system  mortality/aging  nervous system 
     normal 

    ATF7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ATF7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Rho Family GTPases
    		MAPK Signaling0.51
    		ILK Signaling0.45
    2SMAD Signaling Network
    		SMAD Signaling Network1.00
    3Regulation of retinoblastoma protein
    		Regulation of retinoblastoma protein1.00
    4PKC-Theta Pathway
    		ITK and TCR Signaling0.54
    5TWEAK Pathway
    		TNF Signaling0.40

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ATF7 (see all 9)
        MAPK Signaling
    PI3K Signaling in B-Lymphocyte
    TNF Signaling
    iNOS Signaling
    SMAD Signaling Network

    1 BioSystems Pathway for ATF7 
        Regulation of retinoblastoma protein


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ATF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/49 Interacting proteins for ATF7 (P175441, 2, 3 ENSP000003292124) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JDP2Q8WYK22, 3, ENSP000002675694MINT-6699684 MINT-6699624 I2D: score=2 STRING: ENSP00000267569
    JUNBP172752, 3MINT-6699684 MINT-6699624 I2D: score=1 
    JUNDP175352, 3MINT-6699684 MINT-6699624 I2D: score=1 
    OCIAD1Q9NX401, 3EBI-765623,EBI-2683029 I2D: score=1 
    TAF4O002683, ENSP000002529964I2D: score=3 STRING: ENSP00000252996
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA8288576
    GO:0019048virus-host interaction IEA--
    GO:0044419interspecies interaction between organisms ----


    ATF7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ATF7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ATF7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ATF7

    1 HMDB Compound for ATF7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    2 Novoseek chemical compound relationships for ATF7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 37.7 1 15735663 (1)
    leucine 35.6 2 7702840 (1), 8939888 (1)

    Search CenterWatch for drugs/clinical trials and news about ATF7 

    Transcripts
    for ATF7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ATF7 gene (5 alternative transcripts): 
    NM_001130059.1  NM_001130060.1  NM_001206682.1  NM_001206683.1  NM_006856.2  

    Unigene Cluster for ATF7:

    Activating transcription factor 7
    Hs.12286  [show with all ESTs]
    Unigene Representative Sequence: NM_006856
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548446(uc010sok.1) ENST00000420353(uc001sdz.3) ENST00000456903
    ENST00000551087 ENST00000546661 ENST00000588232 ENST00000551480 ENST00000588078
    ENST00000548118(uc001sea.4 uc001seb.4) ENST00000591397 ENST00000550373
    ENST00000589726 ENST00000328463(uc001sdy.3) ENST00000415113(uc010sol.2)


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    hsa-miR-642a hsa-miR-485-3p hsa-miR-3142 hsa-miR-149 hsa-miR-489 hsa-miR-4326 hsa-miR-200b hsa-miR-3612
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK298853.1 AK302907.1 AK310355.1 AK313507.1 BC032433.1 BC042363.1 BC127259.1 BC136302.1 
    BC140006.1 NR_073163.1 X52943.1 X57197.1 

    11 DOTS entries:

    DT.40252235  DT.109024  DT.95350377  DT.453071  DT.443798  DT.91723027  DT.121185200  DT.40254406 
    DT.410741  DT.40131562  DT.95084758 

    24/57 AceView cDNA sequences (see all 57):

    BX093800 X57197 BX643397 CB135343 BU552917 W45531 BI829327 BQ675296 
    BQ073001 BF817643 BP357564 BM825773 CB054833 BI596298 BQ323296 BC032433 
    CB991315 BI667682 BG113231 BM147860 BG203452 AI091018 BC042363 AA679547 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ATF7 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
    SP1:                    -                 -                 -     -     -                                               -     -                     
    SP2:                                      -                       -     -                                               -     -                     
    SP3:                    -                 -                                                                                                         
    SP4:                                      -                                                                                                         
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for ATF7

    Expression
    for ATF7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ATF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCCCTGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ATF7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudHepatoblastsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ATF7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ATF7

    SOURCE GeneReport for Unigene cluster: Hs.12286

    UniProtKB/Swiss-Prot: ATF7_HUMAN, P17544
    Tissue specificity: Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including
    heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta

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    In Situ
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    Orthologs
    for ATF7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ATF7 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Atf71 , 5 activating transcription factor 71, 5 92.62(n)1
    97.32(a)1    		   15 (57.66 cM)5
    2239221  NM_146065.11  NP_666177.11 
     1025366435 
    chicken
    (Gallus gallus)    		 Aves ATF71 activating transcription factor 7 78.26(n)
    90.83(a)    		   769661  XM_003643835.1  XP_003643883.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ATF76
    		 --
    		 87(a)
    		 1 → many
    		 2(73070177-73099099)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.180072 Transcribed sequence with moderate similarity to protein more 78.02(n)    AL965564.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa97a092 Transcribed sequence with weak similarity to protein more 77.36(n)    AL915059.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 22(a)
    		 1 → many
    		 Group13.2(464747-466871)


    ENSEMBL Gene Tree for ATF7 (if available)
    TreeFam Gene Tree for ATF7 (if available) 

    Paralogs
    for ATF7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ATF7 gene
    ENSG000002672812  ATF22  CREB52  
    2 SIMAP similar genes for ATF7 using alignment to 4 protein entries:     ATF7_HUMAN (see all proteins):
    ATF2    CREB5

    ATF7 for paralogs           About GeneDecksing



    Genomic Variants
    for ATF7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1710 NCBI SNPs in ATF7 are shown (see all 1710)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1129612151,2
    		--53903569(+) ACAGGC/TGTGAG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1171738401,2
    		--53903599(+) CCATAG/TTCTTT 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1461372891,2
    		--53903712(+) GATACC/TATATT 1 -- int10--------
    rs1862029661,2
    		--53903839(+) TTTTTG/TTGAGA 1 -- int10--------
    rs1112848451,2
    		C,--53903845(+) TGAGAC/TGGAGT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs2018229391,2
    		--53904308(+) TGTAA-/TC    
       CTAGC    TCTTG     		1 -- int10--------
    rs1910078011,2
    		--53904869(+) TCCAGA/GGACAC 1 -- int10--------
    rs118300381,2
    		C,F,A,H,--53905094(+) ACGGCA/GCGATC 1 -- int14Minor allele frequency- G:0.30NA WA 10
    rs1815024371,2
    		--53905096(+) GGCACA/GATCTT 1 -- int10--------
    rs1489325611,2
    		--53905281(+) AACCCA/GCCTCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ATF7 (53901640 - 54020199 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ATF7: --

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    Disorders / Diseases
    for ATF7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ATF7 for disorders           About GeneDecksing

    OMIM gene information: 606371    OMIM disorders: --

    2 diseases for ATF7:    About MalaCards
    retinoblastoma    breast cancer

    1 Novoseek disease relationship for ATF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 43.7 3 7786026 (2), 11566021 (1)


    Export disorders for ATF7 gene to outside databases

    Publications
    for ATF7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ATF7 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with ATF7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells. (PubMed id 1694576)1, 2, 3 Gaire M.... Kedinger C. (1990)
    2. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. (PubMed id 15735663)1, 2, 9 Hamard P.J....Chatton B. (2005)
    3. Role of the ATFa/JNK2 complex in Jun activation. (PubMed id 10376527)1, 2, 9 De Graeve F....Chatton B. (1999)
    4. A cytoplasmic negative regulator isoform of ATF7 impa irs ATF7 and ATF2 phosphorylation and transcriptional activity. (PubMed id 21858082)1, 2 Diring J....Chatton B. (2011)
    5. p38beta2-mediated phosphorylation and sumoylation of ATF7 are mutually exclusive. (PubMed id 18950637)1, 2 Camuzeaux B....Chatton B. (2008)
    6. Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity. (PubMed id 17264123)1, 2 Hamard P.J....Chatton B. (2007)
    7. ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase. (PubMed id 11278933)1, 3 Peters C.S....Diamond R.H. (2001)
    8. ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers. (PubMed id 8288576)1, 2 Pescini R....Hooft van Huijsduijnen R. (1994)
    9. Structure and expression of the ATFa gene. (PubMed id 8939888)1, 9 Goetz J....Kedinger C. (1996)
    10. Jun and Fos heterodimerize with ATFa, a member of the ATF/CREB family and modulate its transcriptional activity. (PubMed id 8290251)2, 9 Chatton B....Kedinger C. (1994)

    External Searches for ATF7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing ATF7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11016 HGNC: 792 AceView: ATF7 Ensembl:ENSG00000170653 euGenes: HUgn11016
    ECgene: ATF7 H-InvDB: ATF7

    Other Databases showing ATF7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ATF7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ATF7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ATF7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ATF7 gene:
    Search GeneIP for patents involving ATF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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