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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASIP Gene

protein-coding   GIFtS: 55
GCID: GC20P032785

agouti signaling protein

(Previous names: agouti (mouse)-signaling protein, agouti signaling protein,...)
(Previous symbol: AGTIL)
 Explore 18 diseases affiliated with
ASIP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ASIP    

Aliases
for ASIP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Agouti Signaling Protein1 2     Agouti (Mouse)-Signaling Protein1
AGTIL1 2 3 5     Agouti Signaling Protein, Nonagouti Homolog (Mouse)1
ASP1 2 3     AGSW2
Agouti Switch Protein2 3     Agouti Signaling Protein, Nonagouti Homolog2
AGTI2 3     Agouti-Signaling Protein2
SHEP92 5     Nonagouti Homolog2

External Ids:    HGNC: 7451   Entrez Gene: 4342   Ensembl: ENSG000001014407   OMIM: 6002015   UniProtKB: P421273   

Export aliases for ASIP gene to outside databases

Previous GC identifers: GC20P032606 GC20P033516 GC20P033563 GC20P032312 GC20P032848 GC20P029629 GC20P032783


Summaries
for ASIP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ASIP:
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize
pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive
expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility.
This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair
pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in
neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in
adipocytes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ASIP_HUMAN, P42127
Function: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated
signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment)
and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality
of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of
melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes




Genomic Views
for ASIP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASIP gene promoter:
         AML1a   NF-E2 p45   E47   CREB   POU2F1   POU2F1a   deltaCREB   Zic3   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ASIP promoter sequence
   Search SABiosciences Chromatin IP Primers for ASIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2-q12   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.2-q12

ASIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASIP gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P032785:  view genomic region     (about GC identifiers)

Start:
 32,782,375 bp from pter      End:
 32,857,150 bp from pter
Size:
 74,776 bases      Orientation:
 plus strand

Proteins
for ASIP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ASIP_HUMAN, P42127 (See protein sequence)
Recommended Name: Agouti-signaling protein precursor  
Size: 132 amino acids; 14515 Da
Subcellular location: Secreted
5 PDB 3D structures from and Proteopedia for ASIP:
1Y7J (3D)        1Y7K (3D)        2IQW (3D)        2KZA (3D)        2L1J (3D)    
Secondary accessions: Q3SXL2

Explore the universe of human proteins at neXtProt for ASIP: NX_P42127

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P42127

    • ASIP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001663.2  
    ENSEMBL proteins: 
     ENSP00000454804   ENSP00000364092  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: ASIP
    OriGene Protein Over-expression Lysate: ASIP
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    Novus Biologicals ASIP Protein
    Novus Biologicals ASIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ASIP

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS7937887


    ASIP for ontologies           About GeneDecksing



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    Uscn Antibodies for ASIP
    Search ThermoFisher Antibodies for ASIP

    Assay Products for ASIP: 
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    Uscn ELISAs and CLIAs for ASIP

    Protein Domains /
    Families
    for ASIP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ASIP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007733 Agouti

    Graphical View of Domain Structure for InterPro Entry P42127

    ProtoNet protein and cluster: P42127

    1 Blocks protein family: IPB007733 Agouti

    UniProtKB/Swiss-Prot: ASIP_HUMAN, P42127
    Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin
    Similarity: Contains 1 agouti domain


    Function
    for ASIP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ASIP_HUMAN, P42127
    Function: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated
    signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment)
    and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality
    of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of
    melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes

         Genatlas biochemistry entry for ASIP:
    murine agouti (A) signaling protein,homolog,also antagonizing MC4R,predominantly expressed in
    skin,testis,ovary,heart,melanocortin receptor (MC1R) antagonist

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASIP
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ASIP
    SwitchGear 3'UTR luciferase reporter plasmid: ASIP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASIP (see all 4)
    OriGene shRNA RFP: ASIP
    OriGene siRNA: ASIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASIP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ASIP

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASIP (see all 2)
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    GenScript: all cDNA clones in your preferred vector: ASIP (NM_001672)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASIP 

    Cell Line
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    Search LifeMap BioReagents cell lines for ASIP

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ASIP

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS7757071
    GO:0005515protein binding ----
    GO:0031779melanocortin receptor binding ----
    GO:0031781type 3 melanocortin receptor binding IEA--
    GO:0031782type 4 melanocortin receptor binding IEA--


    ASIP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ASIP:
     Increased HPV18 LCR reporter a 

    Animal Models:
         15/24 MGI mutant phenotypes (inferred from 84 alleles) (MGI details for a) (see all 24):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    ASIP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ASIP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Adipogenesis
    		Adipogenesis1.00
    2Insulin-mediated glucose transport
    		Insulin-mediated glucose transport1.00
    3Adenylate cyclase-activating neuropeptides
    		Adenylate cyclase-activating neuropeptides1.00
    4Basal cell carcinoma
    		Melanogenesis0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ASIP
        Adenylate cyclase-activating neuropeptides


    2 BioSystems Pathways for ASIP 
        Adipogenesis
    Insulin-mediated glucose transport


    1         Kegg Pathway  (Kegg details for ASIP):
        Melanogenesis


    ASIP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ASIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/22 Interacting proteins for ASIP (P421273 ENSP000003640924) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MC3RP419683, ENSP000002439114I2D: score=1 STRING: ENSP00000243911
    MC4RP322453, ENSP000002997664I2D: score=1 STRING: ENSP00000299766
    MC5RP330323, ENSP000003180774I2D: score=1 STRING: ENSP00000318077
    MC2RQ017183, ENSP000003338214I2D: score=1 STRING: ENSP00000333821
    MC1RQ017263I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy IEA--
    GO:0007165signal transduction TAS7757071
    GO:0007267cell-cell signaling TAS7757071
    GO:0008343adult feeding behavior IEA--
    GO:0009755hormone-mediated signaling pathway IEA--


    ASIP for ontologies           About GeneDecksing



    Drugs & Compounds
    for ASIP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ASIP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASIP

    1 HMDB Compound for ASIP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    6 Novoseek chemical compound relationships for ASIP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    eumelanin 89.2 4 16914083 (2), 16005546 (1), 11041354 (1)
    alpha msh 79.1 3 16081629 (1), 16914083 (1), 15748644 (1)
    phaeomelanin 76.7 2 15726415 (1)
    acth 46.6 5 9058374 (2), 15748644 (1), 12851336 (1)
    forskolin 11.6 1 9182807 (1)
    lipid 0 2 11395927 (1)

    Search CenterWatch for drugs/clinical trials and news about ASIP 

    Transcripts
    for ASIP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ASIP gene: 
    NM_001672.2  

    Unigene Cluster for ASIP:

    Agouti signaling protein
    Hs.659995  [show with all ESTs]
    Unigene Representative Sequence: NM_001672
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000568305 ENST00000374954(uc002xah.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASIP
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    SwitchGear 3'UTR luciferase reporter plasmid: ASIP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASIP (see all 4)
    OriGene shRNA RFP: ASIP
    OriGene siRNA: ASIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASIP
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASIP (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASIP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ASIP (NM_001672)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASIP 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASIP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASIP

    Additional cDNA sequence: 

    AY805391.1 BC104238.1 BC104239.2 

    1 DOTS entry:

    DT.405132 

    8 AceView cDNA sequences:

    BX280085 NM_001672 AW206665 AI220203 AI378919 W02039 W32238 AI698587 

    GeneLoc Exon Structure


    Expression
    for ASIP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ASIP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ASIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASIP

    SOURCE GeneReport for Unigene cluster: Hs.659995

    UniProtKB/Swiss-Prot: ASIP_HUMAN, P42127
    Tissue specificity: Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and
    foreskin

        SABiosciences Custom PCR Arrays for ASIP
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ASIP

    Orthologs
    for ASIP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ASIP gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia a1 , 5 nonagouti1, 5 84.62(n)1
    80.77(a)1    		   2 (76.83 cM)5
    505181  NM_015770.31  NP_056585.21 
     1547914025 
    chicken
    (Gallus gallus)    		 Aves ASIP1 agouti signaling protein 54.67(n)
    42.4(a)    		   419147  NM_001115079.1  NP_001108551.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BX629346.16
    		 --
    		 38(a)
    		 1 ↔ 1
    		 6(49927795-49934959)


    ENSEMBL Gene Tree for ASIP (if available)
    TreeFam Gene Tree for ASIP (if available) 

    Paralogs
    for ASIP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ASIP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ASIP_HUMAN, P42127
    Polymorphism: Genetic variants in ASIP define the skin/hair/eye pigmentation variation locus 9 (SHEP9) [MIM:611742].
    Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal
    range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter
    pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair
    color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and
    black hair


    10/235 NCBI SNPs in ASIP are shown (see all 235)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs61194811,2
    		C--29629410(+) GGGGCC/TTATGT 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs60597451,2
    		C,H--29630059(+) GCCACC/TTGAGG 2 P L mis1 ese39Minor allele frequency- T:0.00NS EA MN 812
    rs756663851,2
    		C,F,--29630373(+) GGCCTG/TAAGTT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs119079411,2
    		C,F,H,--29630935(+) gacccC/Tgtctc 1 -- int15Minor allele frequency- T:0.43WA NA CSA 125
    rs773420241,2
    		C,--29632083(+) GTTCCC/TGTGCC 1 -- int10--------
    rs1127409251,2
    		--29632115(+) AGGGGC/AACCTG 1 -- int12Minor allele frequency- A:0.04CSA WA 120
    rs789422191,2
    		C,--29632127(+) GGTGGC/TTCTGA 1 -- int10--------
    rs774332801,2
    		C,F,--29632155(+) AGGTCA/C/GAGGGA 1 -- int12CSA 4
    rs614098941,2
    		C,--29632205(+) TGCTTG/AGATTT 1 -- int12Minor allele frequency- A:0.12WA 120
    rs11294141,2
    		C,F,H--29632461(+) CAAACA/CGATCG 2 Q P mis113Minor allele frequency- C:0.00MN NS EA NA 1008

    HapMap Linkage Disequilibrium report for ASIP (32782375 - 32857150 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ASIP: --
    Human Gene Mutation Database (HGMD): ASIP

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASIP
    DNA2.0 Custom Variant and Variant Library Synthesis for ASIP

    Disorders / Diseases
    for ASIP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ASIP for disorders           About GeneDecksing

    OMIM gene information: 600201   
    OMIM disorders: 611742  
    18 diseases for ASIP:    About MalaCards
    skin/hair/eye pigmentation 9, dark/light hair    infertility    obesity    cutaneous malignant melanoma
    basal cell carcinoma    hemoglobinopathy    skin cancer    diabetes mellitus
    familial melanoma    autoimmune hepatitis    vitiligo    melanoma
    hepatocellular carcinoma    breast cancer    hepatitis    carcinoma
    pancreatitis    neuronitis

    5 Novoseek disease relationships for ASIP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 53.2 22 15998953 (4), 12519127 (3), 19384953 (2), 11833005 (2) (see all 7)
    skin cancer 45.6 1 19384953 (1)
    obesity 26.1 6 10509601 (2), 10078851 (2), 9326333 (1)
    niddm 0.93 2 7757071 (1)
    necrosis 0 1 9326333 (1)

    Genetic Association Database (GAD): ASIP
    Human Genome Epidemiology (HuGE) Navigator: ASIP (29 documents)

    Export disorders for ASIP gene to outside databases

    Publications
    for ASIP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASIP gene, integrated from 9 sources (see all 85):
    (articles sorted by number of sources associating them with ASIP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A polymorphism in the agouti signaling protein gene is associated with human pigmentation. (PubMed id 11833005)1, 2, 4, 9 Kanetsky P.A....Rebbeck T.R. (2002)
    2. Structure and function of ASP, the human homolog of the mouse agouti gene. (PubMed id 7757071)1, 2, 3, 9 Wilson B.D.... Barsh G.S. (1995)
    3. Molecular structure and chromosomal mapping of the human homolog of the agouti gene. (PubMed id 7937887)1, 2, 3 Kwon H.-Y.... Woychik R.P. (1994)
    4. The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans. (PubMed id 15726415)1, 4, 9 Bonilla C....Kittles R.A. (2005)
    5. Population differences in the frequency of the agouti signaling protein g.8818a>G polymorphism. (PubMed id 15016309)1, 4, 9 Zeigler-Johnson C....Kanetsky P.A. (2004)
    6. Structures of the agouti signaling protein. (PubMed id 15701517)1, 2 McNulty J.C.... Millhauser G.L. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    9. Agouti signal protein regulation in human melanoma cells. (PubMed id 12519127)1, 9 Voisey J....Van Daal A. (2003)
    10. Effects of recombinant agouti-signaling protein on melanocortin action. (PubMed id 9058374)1, 9 Yang Y.K....Gantz I. (1997)

    External Searches for ASIP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ASIP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 434 HGNC: 745 AceView: ASIP Ensembl:ENSG00000101440 euGenes: HUgn434
    ECgene: ASIP Kegg: 434 H-InvDB: ASIP

    Other Databases showing ASIP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ASIP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASIP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ASIP Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ASIP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ASIP gene:
    Search GeneIP for patents involving ASIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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