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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASCC2 Gene

protein-coding   GIFtS: 48
GCID: GC22M030184

activating signal cointegrator 1 complex subunit 2

  Search for ASCC2
in our new
 Human Malady Compendium 
Biological research products
for ASCC2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Activating Signal Cointegrator 1 Complex Subunit 21 2     DKFZp586O02231
ASC1p1001 2     FLJ215881
ASC-1 Complex Subunit P1002 3     P1001
Trip4 Complex Subunit P1002 3     ASC1P1003

External Ids:    HGNC: 241031   Entrez Gene: 841642   Ensembl: ENSG000001003257   OMIM: 6142165   UniProtKB: Q9H1I83   

Export aliases for ASCC2 gene to outside databases

Previous GC identifers: GC22M028512 GC22M013146


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ASCC2_HUMAN, Q9H1I8
Function: Enhances NF-kappa-B, SRF and AP1 transactivation

Gene Wiki entry for ASCC2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASCC2 gene promoter:
         AhR   Arnt   NF-AT   GATA-1   AREB6   PPAR-alpha   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASCC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ASCC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASCC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.1

ASCC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASCC2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M030184:  view genomic region     (about GC identifiers)

Start:
30,184,597 bp from pter      End:
30,234,271 bp from pter
Size:
49,675 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ASCC2_HUMAN, Q9H1I8 (See protein sequence)
Recommended Name: Activating signal cointegrator 1 complex subunit 2  
Size: 757 amino acids; 86360 Da
Subunit: Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3. The TRIP4 complex interacts with ALKHB3
Sequence caution: Sequence=BAB15089.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ASCC2:
2DI0 (3D)    
Secondary accessions: B7Z8E0 F5H6J9 Q4TT54 Q8TAZ0 Q9H711 Q9H9D6
Alternative splicing: 3 isoforms:  Q9H1I8-1   Q9H1I8-2   Q9H1I8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASCC2: NX_Q9H1I8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H1I8

  • ASCC2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229835.1  NP_115580.2  

    ENSEMBL proteins: 
     ENSP00000305502   ENSP00000403031   ENSP00000380877   ENSP00000414545   ENSP00000397077  
     ENSP00000412382   ENSP00000417032   ENSP00000410531   ENSP00000408930   ENSP00000437570  

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    Uscn Proteins for ASCC2


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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ASCC2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003892 CUE
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q9H1I8

    ProtoNet protein and cluster: Q9H1I8

    1 Blocks protein family: IPB003892 Ubiquitin system component Cue

    UniProtKB/Swiss-Prot: ASCC2_HUMAN, Q9H1I8
    Similarity: Belongs to the ASCC2 family
    Similarity: Contains 1 CUE domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ASCC2_HUMAN, Q9H1I8
    Function: Enhances NF-kappa-B, SRF and AP1 transactivation

    miRNA
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    hsa-miR-124* hsa-miR-3910 hsa-miR-485-5p hsa-miR-1266 hsa-miR-1914* hsa-miR-124 hsa-miR-506 hsa-miR-3652
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCC2

    2 GenomeRNAi human phenotypes for ASCC2:
     Cell cycle / mitosis defect  Increased TP53 protein express 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASCC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/59 Interacting proteins for ASCC2 (Q9H1I82, 3 ENSP000003055024) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CKAP4Q070652, 3MINT-65466 I2D: score=5 
    CUTCQ9NTM92, 3MINT-65485 I2D: score=5 
    DEAF1O753982, 3MINT-65461 I2D: score=5 
    FAF1Q9UNN52, 3MINT-65486 I2D: score=5 
    FUNDC2Q9BWH22, 3MINT-65480 I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ASCC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASCC2
    Search CenterWatch for drugs/clinical trials and news about ASCC2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ASCC2 gene (2 alternative transcripts): 
    NM_001242906.1  NM_032204.4  

    Unigene Cluster for ASCC2:

    Activating signal cointegrator 1 complex subunit 2
    Hs.731754  [show with all ESTs]
    Unigene Representative Sequence: NM_032204
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000307790(uc003agr.3 uc011akr.2) ENST00000487486 ENST00000472433
    ENST00000458594(uc003ags.3) ENST00000397771 ENST00000411532 ENST00000483380
    ENST00000478812 ENST00000464287 ENST00000449900 ENST00000431535 ENST00000495967
    ENST00000412689 ENST00000465667 ENST00000463203 ENST00000495681 ENST00000462454
    ENST00000453160

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASCC2
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ASCC2 (see all 12):
    hsa-miR-124* hsa-miR-3910 hsa-miR-485-5p hsa-miR-1266 hsa-miR-1914* hsa-miR-124 hsa-miR-506 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidASCC2 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: ASCC2
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    Additional cDNA sequence: 

    AK022886.1 AK025241.1 AK222723.1 AK223033.1 AK303257.1 AY013289.1 BC025368.2 BC032760.1 

    24/35 DOTS entries (see all 35):

    DT.438019  DT.99994822  DT.100845891  DT.91932010  DT.91768390  DT.95220746  DT.87016880  DT.75167950 
    DT.100845872  DT.40305489  DT.100845874  DT.100845876  DT.100845882  DT.100845884  DT.100845887  DT.121638339 
    DT.75193506  DT.100764656  DT.100845873  DT.100845879  DT.120630654  DT.95122780  DT.100038919  DT.100038920 

    24/283 AceView cDNA sequences (see all 283):

    BI768453 BQ212978 BI861731 BG403014 CR593980 CB141611 BI861725 CR622774 
    AW402025 BQ691526 AI583136 BU185370 BG253105 BG029103 BX359615 BX389228 
    CR601965 AI872260 AA767252 CR602059 BM707655 BQ427594 BG122284 BX397511 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for ASCC2 (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^
    SP1:                                -     -           -                                               -                                                         
    SP2:                                                                                                  -                                                         
    SP3:                                                                                                                                                            
    SP4:                                -                 -                                               -                                                         
    SP5:                                -     -                                                                                                                     

    ExUns: 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for ASCC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASCC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCGCCTTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ASCC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASCC2

    SOURCE GeneReport for Unigene cluster: Hs.731754

    UniProtKB/Swiss-Prot: ASCC2_HUMAN, Q9H1I8
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ASCC2 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ascc21 , 5 activating signal cointegrator 1 complex subunit 21, 5 86.99(n)1
    87.97(a)1
      11 (2.94 cM)5
    754521  NM_029291.11  NP_083567.11 
     46377475 
    chicken
    (Gallus gallus)
    Aves ASCC21 activating signal cointegrator 1 complex subunit 2 73.31(n)
    75.3(a)
      417016  XM_003642218.1  XP_003642266.1 
    lizard
    (Anolis carolinensis)
    Reptilia ASCC26
    ASCC26
    --
    63(a)
    51(a)
    1 ↔ 1
    possible ortholog
    AAWZ02039942(3386-6532)
    6(59634418-59648297)
    African clawed frog
    (Xenopus laevis)
    Amphibia asc1p100-prov2 ASC-1 complex subunit P100 76.43(n)    BC044110.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636662 hypothetical protein MGC63666 72.69(n)   393414  BC054929.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG27011 CG2701 46.09(n)
    31.3(a)
      31261  NM_130669.2  NP_570025.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G277521 Ubiquitin system component Cue protein 40.01(n)
    27.53(a)
      5007732  NM_001084142.1  NP_001077611.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02050001 hypothetical protein 43.73(n)
    30.39(a)
      4331989  NM_001055847.1  NP_001049312.1 


    ENSEMBL Gene Tree for ASCC2 (if available)
    TreeFam Gene Tree for ASCC2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/924 NCBI SNPs in ASCC2 are shown (see all 924    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117042471,2
    C,H--30184132(+) ACTGGA/CTGAAT 2 -- int10--------
    rs1387898521,2
    --30184252(+) AGGTGA/CCTTCA 2 -- int10--------
    rs733928741,2
    C,--30184336(+) CATAAC/GTGAAT 2 -- int12Minor allele frequency- G:0.08WA 120
    rs1488555831,2
    --30184359(+) AGGACC/TACAGG 2 -- int10--------
    rs1434852821,2
    --30184459(+) GCAGCA/GTCAGA 2 -- int10--------
    rs1884102881,2
    --30184499(+) ATGACA/GGAGAG 2 -- int10--------
    rs1928596201,2
    --30184578(+) ATGTGA/C/GGTCAT 2 -- int10--------
    rs778434301,2
    F,--30184598(+) CAGATC/TGTTTG 2 -- ut311Minor allele frequency- T:0.07WA 118
    rs1401471,2
    C,F,O,A,H,--30184599(+) AGATCG/ATTTGA 2 -- ut3119Minor allele frequency- A:0.20NS EA NA 2064
    rs1416239391,2
    --30184731(+) TCCATC/TCCCAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ASCC2 (30184597 - 30234271 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ASCC2: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    ASCC2 for disorders           About MalaCards

    ASCC2 for disorders           About GeneDecksing

    OMIM gene information: 614216    OMIM disorders: --


    Export disorders for ASCC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASCC2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ASCC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel transcription coactivator complex containing activating signal cointegrator 1. (PubMed id 12077347)1, 2, 3 Jung D.-J.... Lee Y.C. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    5. Toward a complete human genome sequence. (PubMed id 9847074)1, 3 Wilson R. (1998)
    6. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    7. DNA unwinding by ASCC3 helicase is coupled to ALKBH3- dependent DNA alkylation repair and cancer cell proliferation. (PubMed id 22055184)2 Dango S....Shi Y. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84164 HGNC: 24103 AceView: ASCC2 Ensembl:ENSG00000100325 euGenes: HUgn84164
    ECgene: ASCC2 H-InvDB: ASCC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASCC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ASCC2 gene:
    Search GeneIP for patents involving ASCC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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