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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AQP5 Gene

protein-coding   GIFtS: 63
GCID: GC12P050411

aquaporin 5
 Explore 36 diseases affiliated with
AQP5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AQP5    

Aliases
for AQP5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Aquaporin 51 2
AQP-52 3
Aquaporin-51

External Ids:    HGNC: 6381   Entrez Gene: 3622   Ensembl: ENSG000001617987   OMIM: 6004425   UniProtKB: P550643   

Export aliases for AQP5 gene to outside databases

Previous GC identifers: GC12P050649 GC12P050072 GC12P048641 GC12P047386


Summaries
for AQP5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AQP5:
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to
the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary
secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AQP5_HUMAN, P55064
Function: Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions

Gene Wiki entry for AQP5


Genomic Views
for AQP5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AQP5 gene promoter:
         HOXA9   C/EBPbeta   CP2   Sp1   p53   MyoD   LCR-F1   Pax-4a   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AQP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for AQP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AQP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

AQP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P050411:  view genomic region     (about GC identifiers)

Start:
 50,355,279 bp from pter      End:
 50,359,461 bp from pter
Size:
 4,183 bases      Orientation:
 plus strand

Proteins
for AQP5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AQP5_HUMAN, P55064 (See protein sequence)
Recommended Name: Aquaporin-5  
Size: 265 amino acids; 28292 Da
Subcellular location: Membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for AQP5:
3D9S (3D)    
Secondary accessions: Q6FGW8

Explore the universe of human proteins at neXtProt for AQP5: NX_P55064

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55064

    • AQP5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001642.1  
    ENSEMBL proteins: 
     ENSP00000293599  
    Reactome Protein details: P55064
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: AQP5
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    Novus Biologicals AQP5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AQP5

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8621489
    GO:0005902microvillus IEA--
    GO:0009925basal plasma membrane IEA--


    AQP5 for ontologies           About GeneDecksing



    AQP5 Antibody Products: 
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    Assay Products for AQP5: 
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    Uscn ELISAs and CLIAs for AQP5

    Protein Domains /
    Families
    for AQP5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AQP5 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR022357 MIP_CS
     IPR023271 Aquaporin-like
     IPR023276 Aquaporin_5
     IPR000425 MIP

    Graphical View of Domain Structure for InterPro Entry P55064

    ProtoNet protein and cluster: P55064

    1 Blocks protein family: IPB000425 MIP family

    UniProtKB/Swiss-Prot: AQP5_HUMAN, P55064
    Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop
    with the signature motif Asn-Pro-Ala (NPA)
    Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family


    Function
    for AQP5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AQP5_HUMAN, P55064
    Function: Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions

         Genatlas biochemistry entry for AQP5:
    aquaporin 5,water channel forming integral protein,expressed in salivary and lacrymal glands,cornea epithelium,lung,in
    apical but not in basal turn of the cochlea and putatively involved in low frequency hearing (MIP family)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AQP5
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate AQP5:
    hsa-miR-21* hsa-miR-1226 hsa-miR-185* hsa-miR-634 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: AQP5
    OriGene siRNA: AQP5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AQP5

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AQP5 

    Cell Line
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    Search LifeMap BioReagents cell lines for AQP5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP5

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19060904
    GO:0015250water channel activity IDA12801959


    AQP5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for AQP5:
     Decreased Wnt reporter activit  Increased TP53 protein express 

    Animal Models:
         Mouse knock-outs for AQP5: Aqp5tm1Ask Aqp5tm1Amn
         11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Aqp5):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size  hearing/vestibular/ear 
     homeostasis/metabolism  mortality/aging  muscle  no phenotypic analysis  respiratory system 
     vision/eye 

    AQP5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AQP5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Passive Transport by Aquaporins
    		Passive Transport by Aquaporins1.00
    2Selected targets of ESR1
    		Selected targets of ESR11.00
    3Stabilization and expansion of the E-cadherin adherens junction
    		Stabilization and expansion of the E-cadherin adherens junction1.00
    4Regulation of Water Balance by Renal Aquaporins
    		Aquaporin-mediated transport0.84
    5SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for AQP5
        Selected targets of ESR1

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AQP5
        eNOS Signaling

    1 BioSystems Pathway for AQP5 
        Stabilization and expansion of the E-cadherin adherens junction

    3        Reactome Pathways for AQP5
        Transmembrane transport of small molecules
    Aquaporin-mediated transport
    Passive Transport by Aquaporins


    1         Kegg Pathway  (Kegg details for AQP5):
        Salivary secretion


    AQP5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AQP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for AQP5 (P550641, 2, 3 ENSP000002935994) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997501, 2, 3, ENSP000002303214EBI-746103,EBI-724076 MINT-66783 I2D: score=5 STRING: ENSP00000230321
    CREB3O438893I2D: score=1 
    STX4ENSP000003177144STRING: ENSP00000317714
    EXOC3ENSP000003233774STRING: ENSP00000323377
    EXOC4ENSP000002538614STRING: ENSP00000253861
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006833water transport TAS--
    GO:0007588excretion TAS8621489
    GO:0015670carbon dioxide transport IDA19273840
    GO:0030157pancreatic juice secretion IEP12801959
    GO:0042476odontogenesis IEP12522663


    AQP5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AQP5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AQP5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AQP5
    4 Novoseek chemical compound relationships for AQP5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pilocarpine 39.6 2 11773623 (1), 16949105 (1)
    glycerol 13.3 1 17044001 (1)
    calcium 0 3 16537379 (1), 10600522 (1)
    estrogen 0 1 14635794 (1)

    Search CenterWatch for drugs/clinical trials and news about AQP5 

    Transcripts
    for AQP5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AQP5 gene: 
    NM_001651.3  

    Unigene Cluster for AQP5:

    Aquaporin 5
    Hs.298023  [show with all ESTs]
    Unigene Representative Sequence: NM_001651
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293599(uc001rvo.2) ENST00000553132

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate AQP5:
    hsa-miR-21* hsa-miR-1226 hsa-miR-185* hsa-miR-634 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AQP5 (see all 7)
    OriGene shRNA RFP: AQP5
    OriGene siRNA: AQP5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AQP5
    Clone
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    GenScript: all cDNA clones in your preferred vector: AQP5 (NM_001651)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AQP5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AQP5

    Additional cDNA sequence: 

    BC032946.1 CR541989.1 CR542022.1 

    4 DOTS entries:

    DT.212199  DT.100668789  DT.91759665  DT.75101265 

    24/137 AceView cDNA sequences (see all 137):

    AA234161 CR601707 CD676193 BI829283 AA382090 BF726254 BU738309 BM850948 
    CK431171 BM705754 CR542022 AI738904 BF439120 BU735096 BM695989 BM790056 
    BM706122 BM696473 AI884587 CR625526 CD674895 AW589614 BM706385 BM712412 

    GeneLoc Exon Structure


    Expression
    for AQP5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AQP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGTGGGGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AQP5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungAlveoliAlveolar Epithelial Type 1 CellsLung
    KidneyRenal Collecting Duct SystemType B cellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Lung epithelial-like cells (Derivation of lung e...)

    See AQP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AQP5

    SOURCE GeneReport for Unigene cluster: Hs.298023
        SABiosciences Expression via Pathway-Focused PCR Array including AQP5: 
              Osmotic Stress in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP5

    Orthologs
    for AQP5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AQP5 gene from 6/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves AQP51 aquaporin 5 77.19(n)
    76.05(a)    		   431305  XM_001231780.2  XP_001231781.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 74(a)
    74(a)
    		 1 ↔ many
    1 ↔ many
    		 2(96166576-96172077)
    GL344577.1(2456-8097)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG77773 water transporter 41(a)   47F13   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes AQY11 Aqy1p 42.05(n)
    30.23(a)    		   856322   NP_015518.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DELTA-TIP1 aquaporin TIP2-1 50.88(n)
    43.06(a)    		   820870  NM_112495.3  NP_188245.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 13)    		 aquaporin protein, putative, expressed
    (see all 13)    		 31(a)
    31(a)
    (see all 13)    		 many ↔ many
    many ↔ many
    (see all 13)    		 7(15357967-15359502)
    2(35343804-35345585)


    ENSEMBL Gene Tree for AQP5 (if available)
    TreeFam Gene Tree for AQP5 (if available) 

    Paralogs
    for AQP5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AQP5 gene
    ENSG000002504242  AQP22  AQP82  MIP2  AQP12  AQP42  AQP62  
    7 SIMAP similar genes for AQP5 using alignment to 1 protein entry:     AQP5_HUMAN:
    AQP6    AQP2    MIP    DKFZp434D2030    AQP4    AQP1
    AQP8

    AQP5 for paralogs           About GeneDecksing



    Genomic Variants
    for AQP5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/194 NCBI SNPs in AQP5 are shown (see all 194)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1869151421,2
    		--50353506(+) CCCCAA/GTGGCC 1 -- us2k10--------
    rs1415982771,2
    		--50353598(+) CATGAC/TTGGCT 1 -- us2k10--------
    rs1504822971,2
    		--50354148(+) GAGAGA/GGTGGT 1 -- us2k10--------
    rs1922280391,2
    		--50354267(+) GAGACC/TGAGAA 1 -- us2k10--------
    rs1155085421,2
    		--50354399(+) TGAGAG/CAAATG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1852258231,2
    		--50354403(+) AGAAAC/TGAATA 1 -- us2k10--------
    rs37591291,2
    		C,F,H,--50354437(+) AGCAAA/CAGGCA 1 -- us2k116Minor allele frequency- C:0.08EA NS NA WA 2788
    rs1383014021,2
    		--50354496(+) AGGTGA/GAGAAC 1 -- us2k10--------
    rs1885429131,2
    		--50354529(+) GACCTC/TTCGGA 1 -- us2k10--------
    rs1496186621,2
    		--50354532(+) CTCTCA/GGAGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AQP5 (50355279 - 50359461 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for AQP5
         1 Indel: 71504
    Human Gene Mutation Database (HGMD): AQP5

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for AQP5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AQP5 for disorders           About GeneDecksing

    OMIM gene information: 600442    OMIM disorders: --

    20/36 diseases for AQP5 (see all 36):    About MalaCards
    dry eye syndrome    excessive tearing    keratoconjunctivitis sicca    congenital diaphragmatic hernia
    chronic obstructive pulmonary disease    idiopathic pulmonary fibrosis    dacryoadenitis    cystic fibrosis
    allergic rhinitis    sjogren's syndrome    pulmonary fibrosis    meniere's disease
    menieres disease    hernia    respiratory failure    fibrosis
    rhinitis    pterygium    keratoconjunctivitis    pulmonary disease

    2 diseases from the University of Copenhagen DISEASES database for AQP5:
    Respiratory failure     Sjogren's syndrome

    7 Novoseek disease relationships for AQP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xerostomia 58.2 3 11232635 (1), 10476940 (1), 15640830 (1)
    sjogrens syndrome 55.1 12 11247557 (3), 15640830 (2), 15940770 (2), 11232635 (1) (see all 6)
    dry eye syndromes 51.9 1 11247557 (1)
    nasal polyps 47.1 27 19166033 (7), 15938209 (5), 15715403 (2)
    asthma 0 5 18647319 (3), 11707570 (1)
    tumors 0 8 16242760 (5), 18478076 (1)
    cystic fibrosis 0 1 12801959 (1)

    Human Genome Epidemiology (HuGE) Navigator: AQP5 (5 documents)

    Export disorders for AQP5 gene to outside databases

    Publications
    for AQP5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AQP5 gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with AQP5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human aquaporin-5 gene. Molecular characterization and chromosomal localization. (PubMed id 8621489)1, 2, 3, 9 Lee M.D.... Agre P. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer. (PubMed id 18478076)1, 9 Chae Y.K....Moon C. (2008)
    4. Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. (PubMed id 16537379)1, 9 Sidhaye V.K....King L.S. (2006)
    5. Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML). (PubMed id 18612408)1, 9 Chae Y.K....Moon C. (2008)
    6. Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium. (PubMed id 18042467)1, 9 Woo J....Moon C. (2008)
    7. Comparative expression analysis of aquaporin-5 (AQP5) in keratoconic and healthy corneas. (PubMed id 18449356)1, 9 Garfias Y....Zenteno J.C. (2008)
    8. Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands. (PubMed id 10476940)1, 9 Smith J.K....Berk S.L. (1999)
    9. [Expression and its significance of aquaporin 5 in nasal polyps with or without allergic rhinitis] (PubMed id 19166033)1, 9 Jiang Y....Gao X. (2008)
    10. Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease. (PubMed id 17640479)1, 9 Wang K....Deng Z.P. (2007)

    External Searches for AQP5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AQP5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 362 HGNC: 638 AceView: AQP5 Ensembl:ENSG00000161798 euGenes: HUgn362
    ECgene: AQP5 Kegg: 362 H-InvDB: AQP5

    Other Databases showing AQP5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AQP5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AQP5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AQP5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AQP5 gene:
    Search GeneIP for patents involving AQP5

    GeneCards and IP:
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