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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APCS Gene

protein-coding   GIFtS: 64
GCID: GC01P159557

amyloid P component, serum

 Explore 22 diseases affiliated with
APCS via our new
 Human Malady Compendium 
Biological research products
for APCS
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Amyloid P Component, Serum1 2     MGC881591
SAP1 2 3 5     Pentaxin-Related1
PTX21 2 3     Serum Amyloid P-Component2
9.5S Alpha-1-Glycoprotein2 3     

External Ids:    HGNC: 5841   Entrez Gene: 3252   Ensembl: ENSG000001327037   OMIM: 1047705   UniProtKB: P027433   

Export aliases for APCS gene to outside databases

Previous GC identifers: GC01P157349 GC01P155289 GC01P156335 GC01P156774 GC01P156370 GC01P157824 GC01P130914


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APCS:
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a
characteristic pentameric organization. These family members have considerable sequence homology which is thought to
be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid
cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of
chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the
possibility that it is involved in dealing with apoptotic cells in vivo. (provided by RefSeq, Sep 2008)

UniProtKB/Swiss-Prot: SAMP_HUMAN, P02743
Function: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
May also function as a calcium-dependent lectin

Gene Wiki entry for APCS (Serum amyloid P component)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APCS gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   STAT5A   NF-E2 p45   Nkx3-1 v2   Zic1   STAT3   Nkx3-1 v3   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPCS promoter sequence
   Search SABiosciences Chromatin IP Primers for APCS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APCS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q23   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q21-q23

APCS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APCS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159557:  view genomic region     (about GC identifiers)

Start:
159,557,615 bp from pter      End:
159,558,661 bp from pter
Size:
1,047 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SAMP_HUMAN, P02743 (See protein sequence)
Recommended Name: Serum amyloid P-component precursor  
Size: 223 amino acids; 25387 Da
Cofactor: Binds 2 calcium ions per subunit
Subunit: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits
Subcellular location: Secreted
Mass spectrometry: Mass=25462.5; Mass_error=1.1; Method=Electrospray; Range=20-223; Source=PubMed:8202534;
Mass spectrometry: Mass=25463; Mass_error=3; Method=MALDI; Range=20-223; Source=PubMed:15174148;
Mass spectrometry: Mass=1285.78; Method=MALDI; Range=213-223; Source=PubMed:15174148;
Mass spectrometry: Mass=1186.71; Method=MALDI; Range=213-222; Source=PubMed:15174148;
6/9 PDB 3D structures from and Proteopedia for APCS (see all 9):
1GYK (3D)        1LGN (3D)        1SAC (3D)        2A3W (3D)        2A3X (3D)        2A3Y (3D)    

Explore the universe of human proteins at neXtProt for APCS: NX_P02743

Post-translational modifications:

  • N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP).
  • Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P02743

  • APCS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001630.1  
    ENSEMBL proteins: 
     ENSP00000255040  
    Reactome Protein details: P02743
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for APCS (Pentraxin 2/SAP)
    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate: APCS
    OriGene Custom Protein Services for APCS 
    GenScript Custom Purified and Recombinant Proteins Services for APCS
    Novus Biologicals APCS Proteins
    Novus Biologicals APCS Lysate
    Sino Biological Recombinant Protein for APCS
    ProSpec Recombinant Protein for APCS
    Uscn Proteins for APCS

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0031012colocalizes with extracellular matrix IDA--
    GO:0043234protein complex IEA--


    APCS for ontologies           About GeneDecksing



    APCS Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of APCS
    R&D Systems Antibodies for APCS (Pentraxin 2/SAP)
    OriGene Antibodies (see all 4): APCS
    OriGene Custom Antibody Services for APCS 
    GenScript Superior Antibodies for APCS
    Novus Biologicals APCS Antibodies
    Abcam antibodies for APCS 
    Uscn Antibodies for APCS
    ThermoFisher Antibodies for APCS

    Assay Products for APCS: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for APCS
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for APCS


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    APCS for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013320 ConA-like_subgrp
     IPR001759 Pentaxin
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P02743

    ProtoNet protein and cluster: P02743

    1 Blocks protein family: IPB001759 Pentaxin

    UniProtKB/Swiss-Prot: SAMP_HUMAN, P02743
    Similarity: Belongs to the pentaxin family
    Similarity: Contains 1 pentaxin domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SAMP_HUMAN, P02743
    Function: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
    May also function as a calcium-dependent lectin

         Genatlas biochemistry entry for APCS:
    amyloid P component,serum,pentaxin (pentraxin) family

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: APCS
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APCS
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate APCS
    SwitchGear 3'UTR luciferase reporter plasmidAPCS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APCS (see all 7)
    OriGene shRNA RFP: APCS
    OriGene siRNA: APCS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APCS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for APCS

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APCS (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APCS
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: APCS (NM_001639)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APCS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APCS 

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    GenScript Custom overexpressing Cell Line Services for APCS
    Search LifeMap BioReagents cell lines for APCS

    In Situ Assay
    Products:
       

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for APCS

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030246carbohydrate binding ----
    GO:0046872metal ion binding IEA--
    GO:0051082unfolded protein binding TAS10812074


    APCS for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for APCS:
     Decreased viability of wild-ty 

    Animal Models:
         Mouse knock-outs for APCS: Apcstm1Mpe Apcstm1Smae
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Apcs):
     hematopoietic system  immune system  mortality/aging  other  renal/urinary system 

    APCS for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selected targets of C/EBPbeta
    Selected targets of C/EBPbeta1.00
    2Disease
    Disease1.00
    3Amyloid precursor proteins form ordered fibrils
    Amyloids0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for APCS
        Selected targets of C/EBPbeta


    2        Reactome Pathways for APCS
        Amyloids
    Disease



    APCS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APCS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for APCS (P027432, 3 ENSP000002550404) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOT2P005052, 3, ENSP000002452064MINT-8249003 I2D: score=2 STRING: ENSP00000245206
    HES1Q144692, 3, ENSP000002324244MINT-8249014 I2D: score=2 STRING: ENSP00000232424
    C4BPAP040033, ENSP000003560374I2D: score=2 STRING: ENSP00000356037
    CALUO438523, ENSP000002493644I2D: score=2 STRING: ENSP00000249364
    FCGR3AP086373, ENSP000003569464I2D: score=2 STRING: ENSP00000356946
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS10812074
    GO:0006953acute-phase response TAS2987268
    GO:0051131chaperone-mediated protein complex assembly TAS10972085


    APCS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APCS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APCS

    1 HMDB Compound for APCS    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for APCS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-Galactopyranoside-- --target--17139284 17016423
    BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE-- --target--10592235
    BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE-- --target--10592235

    8 Novoseek chemical compound relationships for APCS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    saquinavir 67.7 1 12182226 (1)
    indinavir 64.1 2 12182226 (1), 10532286 (1)
    ganglioside 29.7 1 12733985 (1)
    phosphatidylethanolamine 26 5 11441067 (3), 8999915 (1)
    ceramide 25.2 1 12733985 (1)
    phospholipid 23.1 2 11441067 (1), 12609906 (1)
    anti-fungal 19.7 1 10450995 (1)
    lipid 0 1 15530444 (1)

    Search CenterWatch for drugs/clinical trials and news about APCS / SAMP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APCS gene: 
    NM_001639.3  

    Unigene Cluster for APCS:

    Amyloid P component, serum
    Hs.507080  [show with all ESTs]
    Unigene Representative Sequence: BG533315
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000255040(uc001ftv.3)

    miRNA
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    OriGene 3'-UTR Clone: APCS
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APCS
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    SwitchGear 3'UTR luciferase reporter plasmidAPCS 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APCS (see all 7)
    OriGene shRNA RFP: APCS
    OriGene siRNA: APCS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APCS
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APCS (see all 3)
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    GenScript: all cDNA clones in your preferred vector: APCS (NM_001639)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APCS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APCS 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APCS
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APCS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APCS

    Additional cDNA sequence: 

    BC007039.1 BC007058.1 BC070178.1 BT006750.1 CR450313.1 M10944.1 X04608.1 

    3 DOTS entries:

    DT.413275  DT.91827599  DT.92447980 

    24/177 AceView cDNA sequences (see all 177):

    CK904372 C20929 AV659408 AV653918 AV659282 BG618599 BG563512 BG567937 
    BG618365 BG617725 BG566381 BG567133 BG567550 BG567262 BG545350 BG565555 
    BG569117 BG568561 BG617610 BG566056 BG617132 CA426849 BG533315 BG562396 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APCS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGGACTCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See APCS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APCS

    SOURCE GeneReport for Unigene cluster: Hs.507080

    UniProtKB/Swiss-Prot: SAMP_HUMAN, P02743
    Tissue specificity: Found in serum and urine

        SABiosciences Expression via Pathway-Focused PCR Arrays including APCS: 
              Innate & Adaptive Immune Responses in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APCS
    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for APCS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for APCS gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CRP1 C-reactive protein, pentraxin-related 56.07(n)
    47.66(a)
      429786  NM_001039564.1  NP_001034653.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    --
    44(a)
    42(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    GL343640.1(60685-66597)
    GL343640.1(53931-55784)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-270n8.16
    si:ch211-270n8.1
    20(a)
    1 → many
    13(20508374-20510467)


    ENSEMBL Gene Tree for APCS (if available)
    TreeFam Gene Tree for APCS (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APCS gene
    NPTX22  CBX62  CRP2  PTX42  NPTX12  NPTXR2  PTX32  
    2 SIMAP similar genes for APCS using alignment to 1 protein entry:     SAMP_HUMAN:
    CRP    MPTX

    APCS for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for APCS
    PGOHUM00000245032 PGOHUM00000245035


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/123 NCBI SNPs in APCS are shown (see all 123    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1893625971,2
    --159555892(+) AAGTAC/TGAAAG 1 -- us2k10--------
    rs1808684881,2
    --159555915(+) GTATAG/TTTGGG 1 -- us2k10--------
    rs28086461,2
    C,F,A,--159555924(+) GGATAT/ATAGAA 1 -- us2k11Minor allele frequency- A:0.41WA 118
    rs353118611,2
    C,--159556051(+) ACTATA/GACCAT 1 -- us2k12Minor allele frequency- G:0.04NA EA 122
    rs1849238581,2
    --159556080(+) ATTAAC/TGTGGA 1 -- us2k10--------
    rs1477252361,2
    --159556140(+) CAAGAC/GAGTAT 1 -- us2k10--------
    rs1897673861,2
    --159556333(+) ATAATC/GCCAAC 1 -- us2k10--------
    rs1420279321,2
    --159556341(+) AACTTC/TATCAC 1 -- us2k10--------
    rs104943271,2
    F,--159556451(+) GAAGGA/TTACTT 1 -- us2k16Minor allele frequency- T:0.09NS NA 226
    rs37538701,2
    C,F,A,H,--159556466(-) CTCTAA/TCATTG 1 -- us2k120Minor allele frequency- T:0.33EA NS NA WA CSA 2370

    HapMap Linkage Disequilibrium report for APCS (159557615 - 159558661 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for APCS: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APCS
    DNA2.0 Custom Variant and Variant Library Synthesis for APCS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    APCS for disorders           About GeneDecksing

    OMIM gene information: 104770    OMIM disorders: --

    UniProtKB/Swiss-Prot: SAMP_HUMAN, P02743
  • Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid
  • deposits

    20/22 diseases for APCS (see all 22):    About MalaCards
    candida glabrata    carpal tunnel syndrome    amyloidosis, secondary    candidiasis
    amyloidosis    systemic lupus erythematosus    oral candidiasis    lupus erythematosus
    pulmonary fibrosis    polyneuropathy    endocarditis    hepatitis b
    parkinson's disease    vaginitis    fibrosis    alzheimer's disease
    dementia    influenza    immunodeficiency    atherosclerosis

    3 diseases from the University of Copenhagen DISEASES database for APCS:
    Amyloidosis     Polyneuropathy     Alzheimer's disease

    6 Novoseek disease relationships for APCS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    candidiasis 69.4 3 11556759 (1), 12437091 (1), 17472610 (1)
    oropharyngeal 51.2 1 17472610 (1)
    response acute phase 42.7 1 16380821 (1)
    immunodeficiency 19.8 4 12182226 (1), 10532286 (1), 15770446 (1), 15094164 (1)
    inflammation 19.3 1 17138933 (1)
    aids 16.6 1 10770752 (1)

    Genetic Association Database (GAD): APCS
    Human Genome Epidemiology (HuGE) Navigator: APCS (11 documents)

    Export disorders for APCS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APCS gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with APCS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1. (PubMed id 2987268)1, 2, 3 Mantzouranis E.C.... Colten H.R. (1985)
    2. Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease. (PubMed id 15649951)1, 4, 9 Soares M.L....Buxbaum J.N. (2005)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    5. Proteomic characterization of novel serum amyloid P component variants from human plasma and urine. (PubMed id 15174148)1, 2 Kiernan U.A.... Nelson R.W. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Crystal structure of a decameric complex of human serum amyloid P component with bound dAMP. (PubMed id 9217261)1, 2 Hohenester E.... Wood S.P. (1997)
    8. Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure. (PubMed id 8202534)1, 2 Pepys M.B.... Dwek R.A. (1994)
    9. Structure of pentameric human serum amyloid P component. (PubMed id 8114934)1, 2 Emsley J.... Wood S.P. (1994)
    10. Isolation and characterization of the complete complementary and genomic DNA sequences of human serum amyloid P component. (PubMed id 3029048)1, 2 Ohnishi S.... Arao T. (1986)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 325 HGNC: 584 AceView: APCS Ensembl:ENSG00000132703 euGenes: HUgn325
    ECgene: APCS H-InvDB: APCS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APCS Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Serum_Amyloid_P_Component

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APCS gene:
    Search GeneIP for patents involving APCS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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